SynthesisThe journal of nutrition, health & aging2017
Efficacy of a Disease-Specific Nutritional Support for Pressure Ulcer Healing: A Systematic Review and Meta-Analysis.
Synthesis in The journal of nutrition, health & aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pressure Ulcers in Patients Receiving Enteral Nutrition Therapy. What is the Relationship With Gut Microbiota?
Use of a Hypercaloric and Hyperprotein Supplement Enriched with Immunonutrients in Multi-pathological Malnourished Patients to Improve the Incidence and Prevalence of Pressure Sores: a Randomized Controlled Trial
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Effectiveness of dietary interventions in individuals with diabetes for preventing and healing chronic wounds; a systematic review with meta-analysis.Diabetic medicine : a journal of the British Diabetic Association · 2025Pooled it
- Nutritional interventions for preventing and treating pressure ulcers.The Cochrane database of systematic reviews · 2024Pooled it
- The use of oral and enteral tube-fed arginine supplementation in pressure injury care: A systematic review and meta-analysis.Nursing open · 2022Pooled it
- Trial
- Impact of Albumin and Amino Acids Replacement Therapy, and Protein-Rich Nutrition on Pressure Ulcer Healing in Malnourished Geriatric and Palliative Patients: A Multidisciplinary Clinical-Laboratory Study.Journal of clinical medicine · 2026Article
- Nutritional supplementation is associated with improved wound reduction during negative pressure wound therapy in complex wounds: a retrospective cohort study.Frontiers in surgery · 2026Article
- Metabolomic risk predictors of diabetic foot complications: A longitudinal observational study in type 1 diabetes.Diabetes, obesity & metabolism · 2025Observational
- Implementation and clinical impact of an interdisciplinary tool to promote skin integrity after flap surgery in Veterans with spinal cord injury.The journal of spinal cord medicine · 2025Article
- Prevalence of skin injuries related to medical adhesives in Brazilian hospitals: a multicenter study.Revista brasileira de enfermagem · 2025Article
- Psychological impact of caregiving: anxiety and depression levels among caregivers of patients with pressure ulcers.Revista da Escola de Enfermagem da U S P · 2025Article
- Cannabinoids in Integumentary Wound Care: A Systematic Review of Emerging Preclinical and Clinical Evidence.Pharmaceutics · 2024Review
- Causal association of micronutrients and supplements with pressure ulcer: A Mendelian randomization study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Article
- The prevalence of using complementary and alternative medicine products among patients with pressure ulcer.BMC complementary medicine and therapies · 2022Article
- Effects of Caffeine Consumption on Autologous Full-Thickness Skin Graft Healing in an Animal Model.Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India · 2021Article
- Guidelines for parenteral and enteral nutrition in geriatric patients in China.Aging medicine (Milton (N.S.W)) · 2020Article
- Optimizing Nutrition Care for Pressure Injuries in Hospitalized Patients.Advances in wound care · 2019Review
- Nutritional management of older hospitalised patients with pressure injuries.International wound journal · 2019Article
- Prevalence of Pressure Ulcer and Nutritional Factors Affecting Wound Closure Success in Thailand.Materia socio-medica · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this systematic review was to summarize the evidence on the efficacy of high-calorie, high-protein nutritional formula enriched with arginine, zinc, and antioxidants (disease-specific support) in patients with pressure ulcers (PUs).
methodsRandomized controlled trials in English published from January 1997 until October 2015 were searched for in electronic databases (EMBASE, Medline, PubMed, and CINAHL). Studies comparing a disease-specific nutritional support (oral supplements or tube feeding) to a control nutritional intervention enabling the satisfaction of energy requirements regardless of the use of high-calorie formula or placebo or no support for at least 4 weeks were considered eligible. Study outcomes were the percentage of change in PU area, complete healing and reduction in the PU area ≥40% at 8 weeks, and the percentage of change in area at 4 weeks.
resultsA total of 3 studies could be included in the meta-analysis. Compared with control interventions, formulas enriched with arginine, zinc and antioxidants resulted in significantly higher reduction in ulcer area (-15.7% [95%CI, -29.9, -1.5]; P=0.030; I2=58.6%) and a higher proportion of participants having a 40% or greater reduction in PU size (OR=1.72 [95%CI, 1.04, 2.84]; P=0.033; I2=0.0%) at 8 weeks. A nearly significant difference in complete healing at 8 weeks (OR=1.72 [95%CI, 0.86, 3.45]; P=0.127; I2=0.0%) and the percentage of change in the area at 4 weeks (-7.1% [95%CI, -17.4, 3.3]; P=0.180; I2=0.0%) was also observed.
conclusionsThis systematic review shows that the use of formulas enriched with arginine, zinc and antioxidants as oral supplements and tube feeds for at least 8 weeks are associated with improved PU healing compared with standard formulas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.