ArticleThe journal of nutrition, health & aging2017
Frailty in Relation to the Risk of Alzheimer's Disease, Dementia, and Death in Older Chinese Adults: A Seven-Year Prospective Study.
Article in The journal of nutrition, health & aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Multi-domain prognostic models used in middle-aged adults without known cognitive impairment for predicting subsequent dementia.The Cochrane database of systematic reviews · 2023Pooled it
- Frailty status and the risk of dementia, Alzheimer's disease: a meta-analysis of observational studies.Frontiers in neurologyPooled it
- Integrating frailty into decision-making for disease-modifying therapies in Alzheimer's disease: a proposed expert-opinion based approach.The journal of prevention of Alzheimer's disease · 2026Review
- The Association Between Urbanization and Frailty Status in China.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Gait kinematics and kinetics in patients with different grades of meniscus injury: A cross-sectional study.PloS one · 2026Article
- Intrinsic capacity in Lewy body dementia: a review.The Journal of frailty & aging · 2025Review
- Associations of neurodegenerative and cerebrovascular neuropathology with frailty in a diverse sample.Acta neuropathologica communications · 2025Article
- Frailty in motion: Amnestic mild cognitive impairment and Alzheimer's disease cohorts display heterogeneity in multimorbidity classification and longitudinal transitions.Journal of Alzheimer's disease : JAD · 2025Article
- Bidirectional association between depression and cognition in Chinese middle-aged and older women: a 10-year longitudinal study.Frontiers in psychiatry · 2025Article
- Integrated care for older people improved intrinsic capacity in elderly patients: a case control study.BMC geriatrics · 2024Article
- To Be Frail or Not to Be Frail: This Is the Question-A Critical Narrative Review of Frailty.Journal of clinical medicine · 2024Review
- Dementia risk prediction modelling in low- and middle-income countries: current state of evidence.Frontiers in epidemiology · 2024Review
- Frailty and risk of adverse outcomes among community-dwelling older adults in China: a comparison of four different frailty scales.Frontiers in public health · 2023Article
- A frailty index based on routine laboratory data predicts increased risk of mortality in Chinese community-dwelling adults aged over 55 years: a five-year prospective study.BMC geriatrics · 2022Article
- Developing and Validating a Primary Care EMR-based Frailty Definition using Machine Learning.International journal of population data science · 2020Article
- CCCDTD5 recommendations on early non cognitive markers of dementia: A Canadian consensus.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Frailty in Rheumatic Diseases.Frontiers in immunology · 2020Review
- Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia.Acta neuropathologica communications · 2018Article
- What's New in Dementia Risk Prediction Modelling? An Updated Systematic Review.Dementia and geriatric cognitive disorders extraReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo explore the relationship of general health decline assessed by frailty and risk of dementia and Alzheimer's disease (AD).
designA seven-year prospective cohort study.
settingSecondary analysis of data from the Beijing Longitudinal Study on Aging.
participantsUrban and rural community-dwelling people aged 60 and older at baseline. MEASUREMENTS: Frailty was quantified using the deficit accumulation-based frailty index (FI), constructed from 40 health deficits at baseline. Dementia was diagnosed by DSM-IIIR. AD and vascular dementia (VaD) were diagnosed by NINCDS-ADRDA and NINDS-AIREN. The relationships between frailty and the risk of dementia, AD and death were evaluated through multivariable models.
resultsOf 2788 participants at baseline (1997), 171 (11.1%) reported a history of dementia. In seven years, 351 people developed dementia (13%: 223 AD and 128 other types of dementia) and 813 died (29%). After adjustment for age, sex, education, and baseline cognition, baseline frailty status significantly associated with Alzheimer's disease and dementia and death. For each deficit accumulated, the odds ratio of death increased by 5.7%, and the odds ratio of dementia increased by 2.9% (p < 0.001).
conclusionFrailty was associated with Alzheimer's disease and dementia over a seven years period. Frailty index might facilitate the identification of older adults at high risk of dementia for the application of the most effective, targeted prevention strategies.
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