SynthesisNature communications2017
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.
Registry-linked trialOpen access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02388854 (Influence of WNT4 VEZT FSHB and SIRT1 Genetic Polymorphisms in the Pathogenesis of Endometriosis), which is not on this map. Cited by 195 papers, 19 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
195citing papers in PubMed, 19 pooled it
35.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of WNT4 VEZT FSHB and SIRT1 Genetic Polymorphisms in the Pathogenesis of Endometriosis: a Case Control Study of the Sardinian Population
Who cites it
195 citing papers in PubMed, 19 syntheses or guidelines pooled it, 330 citations in OpenAlex.
- Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity.Human reproduction (Oxford, England) · 2024Pooled it
- The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.Nature genetics · 2023Pooled it
- Genetic liability to multiple factors and uterine leiomyoma risk: a Mendelian randomization study.Frontiers in endocrinology · 2023Pooled it
- A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes.Cell reports. Medicine · 2022Pooled it
- Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways.Human reproduction (Oxford, England) · 2022Pooled it
- Molecular Drivers of Developmental Arrest in the Human Preimplantation Embryo: A Systematic Review and Critical Analysis Leading to Mapping Future Research.International journal of molecular sciences · 2021Pooled it
- The Effect of Letrozole Combined with Dydrogesterone for Endometriosis in China: A Meta-Analysis.BioMed research international · 2021Pooled it
- Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure.Human reproduction update · 2020Pooled it
- Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank.Communications biology · 2020Pooled it
- Pooled it
- Identifying small-effect genetic associations overlooked by the conventional fixed-effect model in a large-scale meta-analysis of coronary artery disease.Bioinformatics (Oxford, England) · 2020Pooled it
- Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.Nature communications · 2019Pooled it
- Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration.Nature communications · 2019Pooled it
- The association between endometriosis and autoimmune diseases: a systematic review and meta-analysis.Human reproduction update · 2019Pooled it
- Pooled it
- Discovery of common and rare genetic risk variants for colorectal cancer.Nature genetics · 2019Pooled it
- Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.Nature communications · 2018Pooled it
- Japanese GWAS identifies variants for bust-size, dysmenorrhea, and menstrual fever that are eQTLs for relevant protein-coding or long non-coding RNAs.Scientific reports · 2018Pooled it
- Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses.Cancer medicine · 2018Pooled it
- YTHDF3 promotes angiogenesis in endometriosis by enhancing the translation efficiency of PFKFB3.Angiogenesis · 2026Article
135 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
42 authors at 20 institutions in 8 countries.
Yadav SapkotaDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Valgerdur SteinthorsdottirdeCODE Genetics/Amgen, 101 Reykjavik, Iceland.
Andrew P MorrisDepartment of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK.
Amelie FassbenderKULeuven, Department of Development and Regeneration, Organ systems, 3000 Leuven, Belgium.
Nilufer RahmiogluWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Immaculata De VivoHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Julie E BuringHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Futao ZhangInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Todd L EdwardsInstitute of Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA.ORCID 0000-0003-4318-6119
Sarah JonesVanderbilt Genetics Institute, Division of Epidemiology, Institute of Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA.
Dorien OKULeuven, Department of Development and Regeneration, Organ systems, 3000 Leuven, Belgium.
Daniëlle PeterseKULeuven, Department of Development and Regeneration, Organ systems, 3000 Leuven, Belgium.
Kathryn M RexrodeHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Paul M RidkerHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Andrew J SchorkCognitive Science Department, University of California, San Diego, La Jolla, California 92093, USA.
Stuart MacGregorDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.ORCID 0000-0001-6731-8142
Nicholas G MartinDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Christian M BeckerEndometriosis CaRe Centre, Nuffield Dept of Obstetrics &Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Sosuke AdachiDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 950-2181, Japan.
Kosuke YoshiharaDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 950-2181, Japan.ORCID 0000-0002-2254-3378
Takayuki EnomotoDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 950-2181, Japan.
Atsushi TakahashiCenter for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.ORCID 0000-0001-7099-8767
Yoichiro KamataniCenter for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
Koichi MatsudaInstitute of Medical Sciences, The University of Tokyo, Tokyo 108-8639, Japan.ORCID 0000-0001-7292-2686
Michiaki KuboCenter for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
Gudmar ThorleifssondeCODE Genetics/Amgen, 101 Reykjavik, Iceland.
Reynir T GeirssonDepartment of Obstetrics and Gynecology, Landspitali University Hospital, 101 Reykjavik, Iceland.
Unnur ThorsteinsdottirdeCODE Genetics/Amgen, 101 Reykjavik, Iceland.
Leanne M WallaceDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
iPSYCH-SSI-Broad Group
Jian YangInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.ORCID 0000-0003-2001-2474
Digna R Velez EdwardsVanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute of Medicine and Public Health, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA.
Mette NyegaardDepartment of Biomedicine, Aarhus University, DK-8000 Aarhus, Denmark.ORCID 0000-0002-2967-6624
Siew-Kee LowCenter for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
Krina T ZondervanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Stacey A MissmerHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Thomas D'HoogheKULeuven, Department of Development and Regeneration, Organ systems, 3000 Leuven, Belgium.
Grant W MontgomeryDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Daniel I ChasmanHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Kari StefanssondeCODE Genetics/Amgen, 101 Reykjavik, Iceland.
Joyce Y Tung23andMe, Inc., 899 W. Evelyn Avenue, Mountain View, California 94041, USA.
Dale R NyholtDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Brigham and Women's Hospital · USdeCODE Genetics (Iceland) · ISThe University of Queensland · AUCentre for Human Genetics · GBLeuven Institute for Fertility and Embryology · BENiigata University · JPRIKEN Center for Integrative Medical Sciences · JPAarhus University · DKQIMR Berghofer Medical Research Institute · AUQueensland University of Technology · AUJohn Radcliffe Hospital · GBLundbeck Foundation · DKMerck (Germany) · DEReykjavík University · ISSankt Hans Hospital · DKSt. Jude Children's Research Hospital · USTokyo Medical University · JPUniversity of Copenhagen · DKVanderbilt Health · USVanderbilt University Medical Center · US
Funding
Medical Research Council MR/K011480/1Wellcome Trust
Abstract
Endometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide association case-control data sets, totalling 17,045 endometriosis cases and 191,596 controls. In addition to replicating previously reported loci, we identify five novel loci significantly associated with endometriosis risk (P<5 × 10
Indexed as
Genetic Predisposition to DiseaseAdultAgedEndometriosisEstrogen Receptor alphaFemaleGenetic LociGenome-Wide Association StudyGenotypeGonadal Steroid HormonesHumansMetabolic Networks and PathwaysMiddle AgedPolymorphism, Single NucleotideESR1 protein, humanEstrogen Receptor alphaGonadal Steroid Hormones
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT02388854ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.