ArticleNature communications2017
Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 1 of them a synthesis that pooled it.
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Who cites it
104 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mortality Risk and Antibiotic Therapy for Patients with Infections Caused byMedicina (Kaunas, Lithuania) · 2024Pooled it
- Divergent roles of OmpA family proteins in physiology, stress tolerance, and virulence ofVirulence · 2026Article
- Biofilm-mediated antibiotic cross-protection:Microbiology spectrum · 2026Article
- Molecular epidemiology and emergingAntimicrobial agents and chemotherapy · 2026Article
- Awake VV-ECMO for severe pneumonia caused by Elizabethkingia anophelis: a case report.BMC infectious diseases · 2026Article
- Mapping the evolutionary and translational landscape of antibiotic resistance genes in Elizabethkingia anopheles.Molecular genetics and genomics : MGG · 2026Article
- Genomic perspectives on the global dissemination of Elizabethkingia anophelis: unveiling inherent multidrug resistance and virulence determinants.BMC microbiology · 2026Article
- Identification of novel prophages and variants of integrative and conjugative elements in Elizabethkingia anophelis clinical isolates from Seremban, Malaysia.BMC microbiology · 2026Article
- Mosquitoes as vector-based sentinels for tracking bacterial pathogens and antimicrobial resistance in the environment.Frontiers in microbiology · 2026Review
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- Successfully treated case of meningitis caused byIJID regions · 2025Article
- Rare or Unusual Non-Fermenting Gram-Negative Bacteria: Therapeutic Approach and Antibiotic Treatment Options.Antibiotics (Basel, Switzerland) · 2025Review
- Biochemical properties and substrate specificity of GOB-38 in Elizabethkingia anophelis.Scientific reports · 2025Article
- Holy water not so holy: Potential source ofIDCases · 2025Article
- Molecular characterization, comparative genome analysis and resistance determinants of three clinicalFrontiers in microbiology · 2025Article
- Antimicrobial Susceptibility Patterns and Antimicrobial Therapy of Infections Caused byMedicina (Kaunas, Lithuania) · 2024Review
- capD deletion in the Elizabethkingia miricola capsular locus leads to capsule production deficiency and reduced virulence.Veterinary research · 2024Article
- Successful Treatment of Recurrent Extensively Drug-ResistantOpen forum infectious diseases · 2024Article
- Large-scale genomic analysis of Elizabethkingia anophelis.BMC genomics · 2024Article
44 more citing papers are in PubMed but not listed here.
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29 authors.
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No grant is acknowledged in the PubMed record.
Abstract
An atypically large outbreak of Elizabethkingia anophelis infections occurred in Wisconsin. Here we show that it was caused by a single strain with thirteen characteristic genomic regions. Strikingly, the outbreak isolates show an accelerated evolutionary rate and an atypical mutational spectrum. Six phylogenetic sub-clusters with distinctive temporal and geographic dynamics are revealed, and their last common ancestor existed approximately one year before the first recognized human infection. Unlike other E. anophelis, the outbreak strain had a disrupted DNA repair mutY gene caused by insertion of an integrative and conjugative element. This genomic change probably contributed to the high evolutionary rate of the outbreak strain and may have increased its adaptability, as many mutations in protein-coding genes occurred during the outbreak. This unique discovery of an outbreak caused by a naturally occurring mutator bacterial pathogen provides a dramatic example of the potential impact of pathogen evolutionary dynamics on infectious disease epidemiology.
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