SynthesisNature communications2017
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 206 papers, 16 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed, 16 pooled it
14.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
206 citing papers in PubMed, 16 syntheses or guidelines pooled it, 390 citations in OpenAlex.
- Integration of GWAS and single-cell analysis for psoriasis identifies disease-associated cell subtypes and therapeutic targets.Nature communications · 2026Pooled it
- Associations between psoriasis and risk of 33 cancers: a Mendelian randomization study.BMC cancer · 2025Pooled it
- GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.Nature communications · 2025Pooled it
- Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis.Journal of translational medicine · 2025Pooled it
- Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction.Nature communications · 2024Pooled it
- Transcriptomic meta-analysis characterizes molecular commonalities between psoriasis and obesity.Genes and immunity · 2024Pooled it
- Shared Genetic Risk Factors for Multiple Sclerosis/Psoriasis Suggest Involvement of Interleukin-17 and Janus Kinase-Signal Transducers and Activators of Transcription Signaling.Annals of neurology · 2023Pooled it
- Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses.BMC pulmonary medicine · 2023Pooled it
- Shared genetic risk factors and causal association between psoriasis and coronary artery disease.Nature communications · 2022Pooled it
- Psoriasis and cardiovascular disease risk in European and East Asian populations: evidence from meta-analysis and Mendelian randomization analysis.BMC medicine · 2022Pooled it
- Mapping the human genetic architecture of COVID-19.Nature · 2021Pooled it
- Causal Relationship and Shared Genetic Loci between Psoriasis and Type 2 Diabetes through Trans-Disease Meta-Analysis.The Journal of investigative dermatology · 2021Pooled it
- Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target.Nature reviews. Drug discovery · 2020Pooled it
- A Transethnic Mendelian Randomization Study Identifies Causality of Obesity on Risk of Psoriasis.The Journal of investigative dermatology · 2019Pooled it
- Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study.PLoS medicine · 2019Pooled it
- Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling.Human molecular genetics · 2017Pooled it
- Association Study of the Caspase Gene Family and Psoriasis Vulgaris Susceptibility in Northeastern China.BioMed research international · 2019Trial
- Comparative Immunoprofiling in Psoriasis and Psoriasiform Dermatitis Using Inflammatory and Structural Biomarkers: A Preliminary Study.Diagnostics (Basel, Switzerland) · 2026Article
- Psoriasis and Psoriatic Arthritis in Pregnancy: Current Evidence and Clinical Considerations.Cureus · 2026Review
- Synthetic Curcuminoids Combined with Blue-Light-Mediated Photodynamic Therapy for Anti-Inflammatory Effect and Potential Mechanism on Imiquimod-Induced Psoriasis-like Proliferation of Keratinocytes.International journal of molecular sciences · 2026Article
146 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors at 16 institutions in 7 countries.
Lam C TsoiDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Philip E StuartDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Chao Tian23andMe, Inc., Mountain View, California 94041, USA.
Johann E GudjonssonDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Sayantan DasDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.ORCID 0000-0001-6346-1590
Matthew ZawistowskiDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.ORCID 0000-0002-3005-083X
Eva EllinghausInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel 24105, Germany.ORCID 0000-0003-2914-3382
Jonathan N BarkerSt John's Institute of Dermatology, Division of Genetics and Molecular Medicine, Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, UK.
Vinod ChandranDepartment of Medicine, Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
Nick DandSt John's Institute of Dermatology, Division of Genetics and Molecular Medicine, Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, UK.ORCID 0000-0002-1805-6278
Kristina Callis DuffinDepartment of Dermatology, University of Utah, Salt Lake City, Utah 84132, USA.
Charlotta EnerbäckDepartment of Dermatology, Linköping University, Linköping SE-581 83, Sweden.
Tõnu EskoEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel 24105, Germany.ORCID 0000-0003-1530-5811
Dafna D GladmanDepartment of Medicine, Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
Per HoffmannInstitute of Human Genetics, University of Bonn, Bonn 53127, Germany.
Külli KingoDermatology Clinic, Tartu University Hospital, Department of Dermatology and Venereology, University of Tartu, Tartu 50417, Estonia.
Sulev KõksDepartment of Pathophysiology, Centre of Translational Medicine and Centre for Translational Genomics, University of Tartu, Tartu 50411, Estonia.
Gerald G KruegerDepartment of Dermatology, University of Utah, Salt Lake City, Utah 84132, USA.
Henry W LimDepartment of Dermatology, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Ulrich MrowietzDepartment of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany.
Sören MuchaInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel 24105, Germany.
Proton RahmanMemorial University, St. John's, Newfoundland, Newfoundland and Labrador, Canada A1B 3X9.
Andre ReisInstitute of Human Genetics, FAU Erlangen-Nürnberg, Erlangen 91054, Germany.ORCID 0000-0002-6301-6363
Trilokraj TejasviDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Richard TrembathDepartment of Medical and Molecular Genetics, King's College London, London WC2R 2LS, UK.
John J VoorheesDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Stephan WeidingerDepartment of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany.
Michael WeichenthalDepartment of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany.ORCID 0000-0002-9060-4961
Xiaoquan WenDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Nicholas Eriksson23andMe, Inc., Mountain View, California 94041, USA.
Hyun M KangDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
David A Hinds23andMe, Inc., Mountain View, California 94041, USA.
Rajan P NairDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Gonçalo R AbecasisDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
James T ElderDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
University of Michigan · US23andMe (United States) · USChristian-Albrechts-Universität zu Kiel · DEClinical Research Center Kiel · DEKing's College London · GBUniversity of Toronto · CAUniversity of Utah · USBroad Institute · USEstonian University of Life Sciences · EEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHenry Ford Hospital · USLinköping University · SEMemorial University of Newfoundland · CATartu University Hospital · EEUniversity of Bonn · DEUniversity of Tartu · EE
Funding
ZINC GLUCONATE GLYCINE LOZENGES &VITAMIN C EFFECTS ON COMMON COLDM01RR000042 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELSTROM, REBECCA L · 1985 to 2007
$40.8MLinkage analysis of familial psoriasis(Supplement)R01AR042742 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 1994 to 2021
$10.1MGenetic and Genomic Dissection of Psoriatic ArthritisR01AR063611 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD, GLADMAN, DAFNA D · 2012 to 2023
$6.2MIdentification of Psoriatic Arthritis Genes in the MHCR01AR050511 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2004 to 2013
$4.2MCombined Analysis of Gene Expression and DNA Variation in PsoriasisR01AR054966 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2007 to 2011
$3.2MFunctional Genomics of PsoriasisR01AR065183 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2013 to 2016
$1.7MDevelopment of a web-based database and research engine for genetic discoveryR44HG006981 · NHGRI · 23ANDME, INC. · PI MOUNTAIN, JOANNA L. · 2013 to 2014
$1.4MGenotyping the NPF Biobank for Psoriasis Susceptibility GenesRC1AR058315 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2009 to 2010
$993kRole of the Psoriasis Associated IL23R Risk Variants on Th17 Biology and FunctionK08AR060802 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUDJONSSON, JOHANN ELI · 2011 to 2015
$636kDesign Approaches for Sequencing Disease-Associated Regions in PsoriasisU01HG005924 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2010 to 2010
$221kMedical Research Council MR/L011808/1NCRR NIH HHS M01 RR000042NHGRI NIH HHS R44 HG006981NHGRI NIH HHS U01 HG005924NIAMS NIH HHS K08 AR060802NIAMS NIH HHS R01 AR042742NIAMS NIH HHS R01 AR050511NIAMS NIH HHS R01 AR054966NIAMS NIH HHS R01 AR063611NIAMS NIH HHS R01 AR065183NIAMS NIH HHS RC1 AR058315Wellcome Trust
Abstract
Psoriasis is a complex disease of skin with a prevalence of about 2%. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for psoriasis to date, including data from eight different Caucasian cohorts, with a combined effective sample size >39,000 individuals. We identified 16 additional psoriasis susceptibility loci achieving genome-wide significance, increasing the number of identified loci to 63 for European-origin individuals. Functional analysis highlighted the roles of interferon signalling and the NFκB cascade, and we showed that the psoriasis signals are enriched in regulatory elements from different T cells (CD8
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyAge of OnsetGene Regulatory NetworksGenetic LociHumansInterferonsNF-kappa BPolymorphism, Single NucleotideProtein Interaction MapsPsoriasisSignal TransductionT-LymphocytesWhite PeopleInterferonsNF-kappa B
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.