Evidence map›Paper›PMID 28536996›Full record

ReviewNeuromolecular medicine2017

Models for Studying Myelination, Demyelination and Remyelination.

I Osorio-Querejeta, M Sáenz-Cuesta, M Muñoz-Culla, D Otaegui

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neuromolecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Viral infections and multiple sclerosis.Drug discovery today. Disease models · 2020
    Review
  14. Calming Down Mast Cells with Ketotifen: A Potential Strategy for Multiple Sclerosis Therapy?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

I Osorio-QuerejetaMultiple Sclerosis Unit, Neuroscience Area, Biodonostia Health Research Institute, Dr. Begiristain s/n, 20014, San Sebastián, Spain.ORCID http://orcid.org/0000-0001-8379-3592
M Sáenz-CuestaMultiple Sclerosis Unit, Neuroscience Area, Biodonostia Health Research Institute, Dr. Begiristain s/n, 20014, San Sebastián, Spain.
M Muñoz-CullaMultiple Sclerosis Unit, Neuroscience Area, Biodonostia Health Research Institute, Dr. Begiristain s/n, 20014, San Sebastián, Spain.
D OtaeguiMultiple Sclerosis Unit, Neuroscience Area, Biodonostia Health Research Institute, Dr. Begiristain s/n, 20014, San Sebastián, Spain. david.otaegui@biodonostia.org.

Funding

Diputación Foral de Gipuzkoa DFG15/006Eusko Jaurlaritza ELKARTEK 16/014Eusko Jaurlaritza PRE_2014_1_7Instituto de Salud Carlos III (ES) CM14/00006
6 · The paper itself

Abstract

One of the most widely studied demyelinating diseases is multiple sclerosis, which is characterised by the appearance of demyelinating plaques, followed by myelin regeneration. Nevertheless, with disease progression, remyelination tends to fail, increasing the characteristic neurodegeneration of the disease. It is essential to understand the mechanisms that operate in the processes of myelination, demyelination and remyelination to develop treatments that promote the production of new myelin, thereby protecting the central nervous system. A huge variety of models have been developed to help improve our understanding of these processes. Nevertheless, no single model allows us to study all the processes involved in remyelination and usually more than one is needed to provide a full picture of related mechanisms. In this review, we summarise the most commonly used models for studying myelination, demyelination and remyelination and we analyse them critically to outline the most suitable ways of using them.

Indexed as

Models, AnimalAnimalsAnimals, Genetically ModifiedAxonsCells, CulturedCoculture TechniquesDemyelinating DiseasesEncephalomyelitis, Autoimmune, ExperimentalHumansMiceMyelin SheathOligodendrocyte Precursor CellsOligodendrogliaSchwann CellsSpecies SpecificityToxicity TestsCell cultureDemyelinationExperimental modelsMultiple sclerosisNeurodegenerationRemyelination

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.