Evidence map›Paper›PMID 28536867›Full record

ArticlePsychopharmacology2017

Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABA

Paola Maccioni, Giancarlo Colombo, Irene Lorrai, Alessandro Zaru, Mauro A M Carai, Gian Luigi Gessa, Antonella Brizzi, Claudia Mugnaini, Federico Corelli

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Delving into the reducing effects of the GABAAlcohol (Fayetteville, N.Y.) · 2023
    Article
  3. Review
  4. Review
  5. Article
  6. GABACurrent topics in behavioral neurosciences · 2022
    Article
  7. The GABAPsychopharmacology · 2021
    Article
  8. Review
  9. The Novel Positive Allosteric Modulator of the GABAFrontiers in cell and developmental biology · 2021
    Article
  10. Potential of GABACNS drugs · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Paola MaccioniNeuroscience Institute, Section of Cagliari, National Research Council of Italy, 09042, Monserrato (CA), Italy.
Giancarlo ColomboNeuroscience Institute, Section of Cagliari, National Research Council of Italy, 09042, Monserrato (CA), Italy. colomb@unica.it.
Irene LorraiNeuroscience Institute, Section of Cagliari, National Research Council of Italy, 09042, Monserrato (CA), Italy.
Alessandro ZaruNeuroscience Institute, Section of Cagliari, National Research Council of Italy, 09042, Monserrato (CA), Italy.
Mauro A M CaraiCagliari Pharmacological Research, 09127, Cagliari (CA), Italy.
Gian Luigi GessaNeuroscience Institute, Section of Cagliari, National Research Council of Italy, 09042, Monserrato (CA), Italy.
Antonella BrizziDepartment of Biotechnology, Chemistry, and Pharmacy, University of Siena, 53100, Siena (SI), Italy.
Claudia MugnainiDepartment of Biotechnology, Chemistry, and Pharmacy, University of Siena, 53100, Siena (SI), Italy.
Federico CorelliDepartment of Biotechnology, Chemistry, and Pharmacy, University of Siena, 53100, Siena (SI), Italy.
National Academies of Sciences, Engineering, and Medicine · USUniversity of Siena · ITUniversity of Cagliari · IT

Funding

European Foundation for Alcohol Research EA 13 20Regione Autonoma della Sardegna CRP-17596
6 · The paper itself

Abstract

RATIONALE AND

objectivesCOR659 [methyl2-(4-chlorophenylcarboxamido)-4-ethyl-5-methylthiophene-3-carboxylate] is a new, positive allosteric modulator (PAM) of the GABA

resultsTreatment with non-sedative doses of COR659 (2.5, 5, and 10 mg/kg; i.p.) suppressed lever-responding for alcohol (15% v/v) in Sardinian alcohol-preferring (sP) rats under the fixed ratio (FR) 4 (FR4) and progressive ratio (PR) schedules of reinforcement; COR659 was more potent and effective than the reference GABA

conclusionsCOR659 might exert its behavioral effects via a composite mechanism: (i) positive allosteric modulation of the GABA

Indexed as

ChocolateSelf AdministrationAnimalsBehavior, AnimalCyclopentanesEthanolGABA ModulatorsMalePyrazolesPyrimidinesRatsRats, WistarReceptor, Cannabinoid, CB1Reinforcement, PsychologySucroseAM4113CyclopentanesEthanolGABA ModulatorsN,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diaminePyrazolesPyrimidinesReceptor, Cannabinoid, CB1SucroseAlcoholAM4113Cannabinoid CB1 receptorChocolateCOR659GABAB receptorGS39783Oral self-administrationPositive allosteric modulatorRat

Identifiers

PMID28536867
OpenAlexW2620169727

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.