Evidence map›Paper›PMID 28536741›Full record

ArticleAIDS and behavior2018

Does Diagnosis Make a Difference? Estimating the Impact of an HIV Medication Adherence Intervention for Persons with Serious Mental Illness.

Natasha Dalseth, Regina Szucs Reed, Michael Hennessy, Marlene M Eisenberg, Michael B Blank

Registry-linked trialOpen access · greenAbstract readComparative StudyEvaluation Study
In one paragraph

Article in AIDS and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00264823 (Nursing Intervention for HIV Regimen Adherence Among Serious Mental Illness), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00264823 phase2completednot on this map

Nursing Intervention for HIV Regimen Adherence Among Serious Mental Illness (SMI)

TypeinterventionalSponsorNational Institute of Nursing Research (NINR)Ran2003 to 2008Enrolled273ConditionsHIV, Mental IllnessArmsUse of Memory Aids to take medications
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Natasha DalsethDepartment of Psychiatry and Behavioral Science, Lewis Katz School of Medicine, Temple University, Episcopal Campus, 100 E Lehigh Ave MAB 305, Philadelphia, PA, 19125, USA. natasha.dalseth@tuhs.temple.edu.ORCID 0000-0003-2980-9383
Regina Szucs ReedDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michael HennessyCampus Edge Advisors LLC, Branford, CT, USA.
Marlene M EisenbergDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michael B BlankDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USHealthcentric Advisors · USTemple University · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6M
Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Knashawn Hodge Morales · 2013 to 2026
$23.5M
The PFT Intervention: Linking triply-diagnosed inpatients to community careR01DA036503 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI BLANK, MICHAEL B · 2013 to 2017
$3.2M
HIV Prevention Program among Substance Abusing SMIR01DA015627 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI BLANK, MICHAEL B · 2003 to 2007
$3.2M
Nursing Intervention for HIV Regimen Adherence among SMIR01NR008851 · NINR · UNIVERSITY OF PENNSYLVANIA · PI BLANK, MICHAEL B · 2003 to 2007
$3.0M
CFAR-Penn Center for AIDS Research P30-AI-45008-18National Institute for Nursing Research RO1-NR-008851NIAID NIH HHS P30 AI045008NIDA NIH HHS R01 DA015627NIDA NIH HHS R01 DA036503NIDA NIH HHS RO1-DA-015627NIMH NIH HHS P30 MH097488NINR NIH HHS R01 NR008851PMHARC-Penn Mental Health AIDS Research Center P30MH097488-04
6 · The paper itself

Abstract

The heightened risk of persons with serious mental illness to contract and transmit human immunodeficiency virus (HIV) is a public health problem. Here we evaluate the interaction between psychiatric diagnosis and response to a community based-intervention targeted at treatment adherence in 236 HIV+ persons with co-occurring mental illness. To examine differential effectiveness of the intervention for categories of patient diagnosis, we reanalyzed the data after stratifying participants into two diagnostic groups: (1) participants with depressive disorders without psychosis and (2) participants with a psychotic or bipolar disorder. Outcomes included viral load and mental health quality of life (SF-12 Mental Health). We found that HIV+ persons with non-psychotic depressive disorders demonstrated a larger decrease in HIV viral load and more improvement in measures of mental health quality of life when compared to HIV+ persons with psychotic and bipolar disorders. We suggest that successful adherence interventions should be informed by psychiatric symptomatology.

trial registrationclinicaltrials.gov 29 identifier NCT00264823.

Indexed as

Drug MonitoringAdultAnti-Retroviral AgentsBipolar DisorderComorbidityDepressive DisorderFemaleHIV InfectionsHumansMaleMedication AdherenceMiddle AgedPsychotic DisordersViral LoadAnti-Retroviral AgentsHIVPATH+Psychiatric diagnosisRoot cause analysisTreatment adherence

Identifiers

PMID28536741
PMCPMC6281165
OpenAlexW2617161396

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.