Evidence map›Paper›PMID 28536677›Full record

ArticleFrontiers in cellular and infection microbiology2017

CcpA Affects Infectivity of

Markus Bischoff, Bodo Wonnenberg, Nadine Nippe, Naja J Nyffenegger-Jann, Meike Voss, Christoph Beisswenger, Cord Sunderkötter, Virginie Molle, Quoc Thai Dinh, Frank Lammert and 5 more

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. The Pathogenicity Mechanisms ofInternational journal of molecular sciences · 2025
    Review
  2. Article
  3. Article
  4. Integrated genomic and proteomic analysis of the mouse-adaptedCurrent research in microbial sciences · 2025
    Article
  5. Article
  6. Pathogens (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Adaptation ofToxins · 2021
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Virulence and Metabolism.Microbiology spectrum · 2019
    Review
  18. Transcriptome, Phenotypic, and Virulence Analysis ofFrontiers in cellular and infection microbiology · 2019
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Markus BischoffInstitute for Medical Microbiology and Hygiene, Saarland UniversityHomburg, Germany.
Bodo WonnenbergInstitute of Anatomy and Cell Biology, Saarland UniversityHomburg, Germany.
Nadine NippeInstitute of Immunology, University of MunsterMunster, Germany.
Naja J Nyffenegger-JannDivision of Infection Biology, Department of Biomedicine, University Hospital BaselBasel, Switzerland.
Meike VossDepartment of Internal Medicine V - Pulmonology, Allergology and Critical Care Medicine, Saarland University HospitalHomburg, Germany.
Christoph BeisswengerDepartment of Internal Medicine V - Pulmonology, Allergology and Critical Care Medicine, Saarland University HospitalHomburg, Germany.
Cord SunderkötterDepartment of Dermatology, University of MunsterMunster, Germany.
Virginie MolleDIMNP, CNRS, Univ MontpellierMontpellier, France.
Quoc Thai DinhDepartment of Experimental Pneumology and Allergology, Saarland University HospitalHomburg, Germany.
Frank LammertDepartment of Medicine II, Saarland University HospitalHomburg, Germany.
Robert BalsDepartment of Internal Medicine V - Pulmonology, Allergology and Critical Care Medicine, Saarland University HospitalHomburg, Germany.
Mathias HerrmannInstitute for Medical Microbiology and Hygiene, Saarland UniversityHomburg, Germany.
Greg A SomervilleSchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska-LincolnLincoln, NE, USA.
Thomas TschernigInstitute of Anatomy and Cell Biology, Saarland UniversityHomburg, Germany.
Rosmarie GauppInstitute for Medical Microbiology and Hygiene, Saarland UniversityHomburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many bacteria regulate the expression of virulence factors via carbon catabolite responsive elements. In Gram-positive bacteria, the predominant mediator of carbon catabolite repression is the catabolite control protein A (CcpA). Hyperglycemia is a widespread disorder that predisposes individuals to an array of symptoms and an increased risk of infections. In hyperglycemic individuals, the bacterium

Indexed as

AnimalsBacterial ProteinsBlood GlucoseCarbonCytokinesFemaleGene DeletionGene Expression Regulation, BacterialHemolysisLungMiceMice, Inbred C57BLMice, Inbred NODMice, ObeseRepressor ProteinsStaphylococcal InfectionsBacterial ProteinsBlood GlucoseCarboncatabolite control proteins, bacteriaCytokinesRepressor ProteinsStaphylococcal Protein AVirulence Factorscarbon catabolic regulationCcpAhyperglycemiainfectivityStaphylococcus aureus

Identifiers

PMID28536677
PMCPMC5422431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.