ArticleFrontiers in physiology2017
A Bio-Realistic Finite Element Model to Evaluate the Effect of Masticatory Loadings on Mouse Mandible-Related Tissues.
Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Influence of bone-specific material properties on finite element modelling of the skull.Royal Society open science · 2026Article
- KDM6B safeguards mineralized tissue homeostasis from mechanical stress through epigenetic control of PIEZO1-mediated mechanotransduction in the mouse incisor.Bone research · 2026Article
- Association Between Occlusal Wear, Viscoelastic Properties, and Pain in Masticatory Muscles in Individuals With or Without Headache and Neck Pain: A Pilot Cross-Sectional Study.International journal of dentistry · 2026Article
- Preclinical perspectives on disorders of the temporomandibular joint: Tracing the past, navigating the present, and shaping the future.The journal of pain · 2025Review
- Effects of dentinogenesis imperfecta, sex, and tooth type on the compositional and structural organization of the dentin-enamel junction in the osteogenesis imperfecta murine model.Archives of oral biology · 2025Article
- A numerical approach to bio-mechanics analysis based on live micro-CT images in the rat temporomandibular joint.Computational and structural biotechnology journal · 2025Article
- Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages.Exploration (Beijing, China) · 2024Article
- Regional variation of the cortical and trabecular bone material properties in the rabbit skull.PloS one · 2024Article
- Unilateral Hypofunction of the Masseter Leads to Molecular and 3D Morphometric Signs of Atrophy in Ipsilateral Agonist Masticatory Muscles in Adult Mice.International journal of molecular sciences · 2023Article
- Collagen cross-link profiles and mineral are different between the mandible and femur with site specific response to perturbed collagen.Bone reports · 2022Article
- Functional Analysis of Rhythmic Jaw Movements Evoked by Electrical Stimulation of the Cortical Masticatory Area During Low Occlusal Loading in Growing Rats.Frontiers in physiology · 2020Article
- Muscle-Bone Crosstalk in the Masticatory System: From Biomechanical to Molecular Interactions.Frontiers in endocrinology · 2020Review
- Review
- A Dynamic Jaw Model With a Finite-Element Temporomandibular Joint.Frontiers in physiology · 2019Article
- A Novel Method to Detect 3D Mandibular Changes Related to Soft-Diet Feeding.Frontiers in physiology · 2017Article
- The jaw is a second-class lever inPeerJ · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice are arguably the dominant model organisms for studies investigating the effect of genetic traits on the pathways to mammalian skull and teeth development, thus being integral in exploring craniofacial and dental evolution. The aim of this study is to analyse the functional significance of masticatory loads on the mouse mandible and identify critical stress accumulations that could trigger phenotypic and/or growth alterations in mandible-related structures. To achieve this, a 3D model of mouse skulls was reconstructed based on Micro Computed Tomography measurements. Upon segmenting the main hard tissue components of the mandible such as incisors, molars and alveolar bone, boundary conditions were assigned on the basis of the masticatory muscle architecture. The model was subjected to four loading scenarios simulating different feeding ecologies according to the hard or soft type of food and chewing or gnawing biting movement. Chewing and gnawing resulted in varying loading patterns, with biting type exerting a dominant effect on the stress variations experienced by the mandible and loading intensity correlating linearly to the stress increase. The simulation provided refined insight on the mechanobiology of the mouse mandible, indicating that food consistency could influence micro evolutionary divergence patterns in mandible shape of rodents.
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