ArticleFrontiers in behavioral neuroscience2017
Aripiprazole Facilitates Extinction of Conditioned Fear in Adolescent Rats.
Article in Frontiers in behavioral neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Investigation of the Protective Effects of Aripiprazole on Methylphenidate-induced Neurotoxicity in Rats.Molecular neurobiology · 2025Article
- Adolescent male and female rats show enhanced latent inhibition of conditioned fear compared to adult rats.Frontiers in behavioral neuroscience · 2025Article
- Intermixed safety cues facilitate extinction retention in adult and adolescent mice.Physiology & behavior · 2023Article
- Age-specific sex effects in extinction of conditioned fear in rodents.Frontiers in behavioral neuroscience · 2023Article
- Pharmacological Implications of Adjusting Abnormal Fear Memory: Towards the Treatment of Post-Traumatic Stress Disorder.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Pharmacological Enhancement of Extinction Retention in Non-stressed Adolescent Rats but Not Those Exposed to Chronic Corticosterone.Frontiers in neuroscience · 2022Article
- Hippocampal neurogenesis mediates sex-specific effects of social isolation and exercise on fear extinction in adolescence.Neurobiology of stress · 2021Article
- Effects of Methamphetamine Exposure on Fear Learning and Memory in Adult and Adolescent Rats.Neurochemical research · 2019Article
- Clinical Therapeutic Strategy and Neuronal Mechanism Underlying Post-Traumatic Stress Disorder (PTSD).International journal of molecular sciences · 2019Review
- Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood.Scientific reports · 2019Article
- Poor between-session recall of extinction learning and hippocampal activation and connectivity in children.Neurobiology of learning and memory · 2018Article
- Elucidating the mechanisms of fear extinction in developing animals: a special case of NMDA receptor-independent extinction in adolescent rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Extinction of Conditioned Fear in Adolescents and Adults: A Human fMRI Study.Frontiers in human neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anxiety disorders are the most common type of mental disorder during adolescence, which is at least partly due to the resistance to extinction exhibited at this age. The dopaminergic system is known to be dysregulated during adolescence; therefore, we aimed to facilitate extinction in adolescent rats using the dopamine receptor 2 partial agonist aripiprazole (Abilify™), and examine the behavioral and neural outcomes. Adolescent rats were conditioned to fear a tone. The next day, rats received extinction 30 min after a systemic injection of either 5 mg/kg aripiprazole or vehicle, and then were tested the following day. For the immunohistochemistry experiment, naïve and "no extinction" conditions were added and rats were perfused either on the extinction day or test day. To assess the activation of neurons receiving dopaminergic input, c-Fos, and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) labeled neurons were quantified in the amygdala and the medial prefrontal cortex (mPFC). Systemic treatment with aripiprazole at the time of extinction significantly reduced freezing at test the next day. This effect was not observed in rats that were fear conditioned but did not receive any extinction. Aripiprazole's facilitation of extinction was accompanied by increased activation of neurons in the mPFC. Taken together, aripiprazole represents a novel pharmacological adjunct to exposure therapy worthy of further examination. The effect of aripiprazole is related to enhanced activation of mPFC neurons receiving dopaminergic innervation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.