ArticleScientific reports2017
The protective effect of human renal sinus fat on glomerular cells is reversed by the hepatokine fetuin-A.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- A comparison study to assess U-Net driven volumetric versus single-slice analysis and MRI sequences with different volume coverage to detect renal sinus fat in people with and without diabetes.Scientific reports · 2026Article
- Association of hepatic steatosis with MRI-defined renal steatosis in type 2 diabetes: a cross-sectional imaging and clinical modeling study.Frontiers in nutrition · 2026Article
- CARDIAL-MS (CArdio-Renal-DIAbetes-Liver-Metabolic Syndrome): a new proposition for an integrated multisystem metabolic disease.Diabetology & metabolic syndrome · 2025Review
- Emerging insights into the role of visceral adipose tissue in diabetic kidney disease.Frontiers in nutrition · 2025Review
- Abdominal adipose tissue and type 2 diabetic kidney disease: adipose radiology assessment, impact, and mechanisms.Abdominal radiology (New York) · 2024Review
- Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease.Nature reviews. Nephrology · 2023Review
- Extracellular Matrix Expression in Human Pancreatic Fat Cells of Patients with Normal Glucose Regulation, Prediabetes and Type 2 Diabetes.International journal of molecular sciences · 2023Article
- Novel Insights in the Physiopathology and Management of Obesity-Related Kidney Disease.Nutrients · 2022Review
- Abdominal periaortic and renal sinus fat attenuation indices measured on computed tomography are associated with metabolic syndrome.European radiology · 2022Article
- Detection of diabetes from whole-body MRI using deep learning.JCI insight · 2021Article
- Renoprotective role of bariatric surgery in patients with established chronic kidney disease.Clinical kidney journal · 2021Article
- Detection and Characterization of Phosphorylation, Glycosylation, and Fatty Acid Bound to Fetuin A in Human Blood.Journal of clinical medicine · 2021Article
- Urinary fetuin-A peptides as a new marker for impaired kidney function in patients with type 2 diabetes.Clinical kidney journal · 2021Article
- The Relationship between Perirenal Fat Thickness and Reduced Glomerular Filtration Rate in Patients with Type 2 Diabetes.Journal of diabetes research · 2020Article
- Article
- Association of obesity with chronic kidney disease in elderly patients with nonalcoholic fatty liver disease.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Article
- Fetuin-A levels are increased in the adipose tissue of diabetic obese humans but not in circulation.Lipids in health and disease · 2018Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal sinus fat (RSF) is a perivascular fat compartment located around renal arteries. In this in vitro and in vivo study we hypothesized that the hepatokine fetuin-A may impair renal function in non alcoholic fatty liver disease (NAFLD) by altering inflammatory signalling in RSF. To study effects of the crosstalk between fetuin-A, RSF and kidney, human renal sinus fat cells (RSFC) were isolated and cocultured with human endothelial cells (EC) or podocytes (PO). RSFC caused downregulation of proinflammatory and upregulation of regenerative factors in cocultured EC and PO, indicating a protective influence of RFSC. However, fetuin-A inverted these benign effects of RSFC from an anti- to a proinflammatory status. RSF was quantified by magnetic resonance imaging and liver fat content by
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