ArticleScientific reports2017
Characterization of Juvenile Hormone Related Genes Regulating Cantharidin Biosynthesis in Epicauta chinensis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Identification of the key regulatory network and genes highly associated with the synthesis of cantharidin in Epicauta chinensis by transcriptome and metabolome analyses.Insect science · 2026Article
- On the history, synthesis, and medicinal use of cantharidin, LB-100, and their analogs.RSC medicinal chemistry · 2026Review
- The Putative Involvement of Bacterial Symbionts in Cantharidin Biogenesis: An Explorative Study in Meloidae Insects.Microbial ecology · 2025Article
- Natural Occurring Terpene Cyclic Anhydrides: Biosynthetic Origin and Biological Activities.Biomolecules · 2024Review
- Functional Study of the Role of theInternational journal of molecular sciences · 2024Article
- Functional studies of McSTE24, McCYP305a1, and McJHEH, three essential genes act in cantharidin biosynthesis in the blister beetle (Coleoptera: Meloidae).Journal of insect science (Online) · 2024Article
- Investigation of sex expression profiles and the cantharidin biosynthesis genes in two blister beetles.PloS one · 2023Article
- Simultaneous silencing of juvenile hormone metabolism genes through RNAi interrupts metamorphosis in the cotton boll weevil.Frontiers in molecular biosciences · 2023Article
- Article
- Drug Discovery Insights from Medicinal Beetles in Traditional Chinese Medicine.Biomolecules & therapeutics · 2021Review
- Diversity of Insect Sesquiterpenoid Regulation.Frontiers in genetics · 2020Review
- Draft Genome of a Blister BeetleFrontiers in genetics · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cantharidin is a defensive toxin biosynthesized by blister beetles. It is well known for medical applications and toxicity. However, the biosynthesis process of cantharidin is still not well understood. In the present study, three genes (methyl farnesoate epoxidase (EcMFE), juvenile hormone acid O-methyltransferase (EcJHAMT) and juvenile hormone epoxide hydrolase (EcJHEH)) were identified from Epicauta chinensis. The temporal and spatial expression patterns of these three genes revealed that the expression levels of EcMFE and EcJHEH were high in the first instar larval stage of E. chinensis with EcJHEH transcripts highest in the fifth larval instar. The expression level of EcJHAMT was significantly higher in the 2
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