ArticleEmerging microbes & infections2017
Aetiology of acute meningoencephalitis in Cambodian children, 2010-2013.
Article in Emerging microbes & infections, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Post-COVID-19 Vaccination Meningitis and Meningoencephalitis: A Systematic Review of Case Series and Case Reports.The American journal of tropical medicine and hygiene · 2025Pooled it
- The neurological complications of chikungunya virus: A systematic review.Reviews in medical virology · 2018Pooled it
- Clinical features and risk factors for severe pediatric scrub typhus in Liangshan Prefecture, China: A retrospective cohort study.BMC pediatrics · 2026Article
- Construction and validation of a predictive model for meningoencephalitis in pediatric scrub typhus based on machine learning algorithms.Emerging microbes & infections · 2025Article
- Development and internal validation of clinical prediction models for scrub typhus and doxycycline-treatable causes in paediatric acute encephalitis syndrome in Karnataka, India: a multicentre, prospective study.The Lancet regional health. Southeast Asia · 2025Article
- Immunity to Non-Dengue Flaviviruses Impacts Dengue Virus Immunoglobulin G Enzyme-Linked Immunosorbent Assay Specificity in Cambodia.The Journal of infectious diseases · 2025Observational
- Microbiological Investigations for Chikungunya Virus in Children With Acute Encephalitis Syndrome in a Non-Outbreak Setting in Southern India.Journal of medical virology · 2025Article
- Dengue encephalopathy in an adult due to dengue virus type 1 infection.BMC infectious diseases · 2024Article
- Article
- Central nervous system infection in a pediatric population in West Java.PLoS neglected tropical diseases · 2023Article
- Etiology of Acute Infectious Meningitis and Meningoencephalitis in Karachi, Pakistan: Retrospective Observational Study from a Tertiary Care Center.The American journal of tropical medicine and hygiene · 2023Observational
- The spatio-temporal distribution of acute encephalitis syndrome and its association with climate and landcover in Vietnam.BMC infectious diseases · 2023Article
- Association of Scrub Typhus in Children with Acute Encephalitis Syndrome and Meningoencephalitis, Southern India.Emerging infectious diseases · 2023Review
- Article
- Case report on meningoenceplapathy in an Indian patient post CoViD vaccination.Bioinformation · 2023Article
- Outbreak of central nervous system infections among children in Thai Binh, Viet Nam.Emerging microbes & infections · 2022Article
- Aetiologies and clinical presentation of central nervous system infections in Vietnamese patients: a prospective study.Scientific reports · 2022Article
- Neurological Disease Associated with Chikungunya in Indonesia.The American journal of tropical medicine and hygiene · 2022Article
- Modelling Japanese encephalitis virus transmission dynamics and human exposure in a Cambodian rural multi-host system.PLoS neglected tropical diseases · 2022Article
- Childhood encephalitis in the Greater Mekong region (the SouthEast Asia Encephalitis Project): a multicentre prospective study.The Lancet. Global health · 2022Observational
Corrections and comments
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Authors and funding
22 authors at 8 institutions in 6 countries.
Funding
Abstract
Acute meningoencephalitis (AME) is associated with considerable morbidity and mortality in children in developing countries. Clinical specimens were collected from children presenting with AME at two Cambodian paediatric hospitals to determine the major aetiologies associated with AME in the country. Cerebrospinal fluid (CSF) and blood samples were screened by molecular and cell culture methods for a range of pathogens previously associated with AME in the region. CSF and serum (acute and convalescent) were screened for antibodies to arboviruses such as Japanese encephalitis virus (JEV), dengue virus (DENV), and chikungunya virus (CHIKV). From July 2010 through December 2013, 1160 children (one month to 15 years of age) presenting with AME to two major paediatric hospitals were enroled into the study. Pathogens associated with AME were identified using molecular diagnostics, cell culture and serology. According to a diagnostic algorithm, a confirmed or highly probable aetiologic agent was detected in 35.0% (n=406) of AME cases, with a further 9.2% (total: 44.2%, n=513) aetiologies defined as suspected. JEV (24.4%, n=283) was the most commonly identified pathogen followed by Orientia tsutsugamushi (4.7%, n=55), DENV (4.6%, n=53), enteroviruses (3.5%, n=41), CHIKV (2.0%, n=23) and Streptococcus pneumoniae (1.6%, n=19). The majority of aetiologies identified for paediatric AME in Cambodia were vaccine preventable and/or treatable with appropriate antimicrobials.
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