Evidence map›Paper›PMID 28536401›Full record

ArticleBiomedicines2015

HGF Modulates Actin Cytoskeleton Remodeling and Contraction in Testicular Myoid Cells.

Angela Catizone, Giulia Ricci, Maria Caruso, Michela Galdieri, Katia Corano Scheri, Virginia Di Paolo, Rita Canipari

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Angela CatizoneDepartment of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Embryology, Sapienza University of Rome, Via A. Scarpa 16, 00161 Rome, Italy. angela.catizone@uniroma1.it.
Giulia RicciDepartment of Experimental Medicine, Histology and Embryology Laboratory, School of Medicine, Second University of Naples, Via Luciano Armanni 5, 80138 Naples, Italy. giulia.ricci@unina2.it.
Maria CarusoDepartment of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Embryology, Sapienza University of Rome, Via A. Scarpa 16, 00161 Rome, Italy. maria.caruso@uniroma1.it.
Michela GaldieriDepartment of Experimental Medicine, Histology and Embryology Laboratory, School of Medicine, Second University of Naples, Via Luciano Armanni 5, 80138 Naples, Italy. michela.galdieri@uniroma1.it.
Katia Corano ScheriDepartment of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Embryology, Sapienza University of Rome, Via A. Scarpa 16, 00161 Rome, Italy. katia.corano@gmail.com.
Virginia Di PaoloDepartment of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Embryology, Sapienza University of Rome, Via A. Scarpa 16, 00161 Rome, Italy. virginia.dipaolo@uniroma1.it.
Rita CanipariDepartment of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Embryology, Sapienza University of Rome, Via A. Scarpa 16, 00161 Rome, Italy. rita.canipari@uniroma1.it.
Sapienza University of Rome · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The presence of the HGF/Met system in the testicular myoid cells was first discovered by our group. However, the physiological role of this pathway remains poorly understood. We previously reported that HGF increases uPA secretion and TGF-β activation in cultured tubular fragments and that HGF is maximally expressed at Stages VII-VIII of the seminiferous epithelium cycle, when myoid cell contraction occurs. It is well known that the HGF/Met pathway is involved in cytoskeletal remodeling; moreover, the interaction of uPA with its receptor, uPAR, as well as the activation of TGF-β have been reported to be related to the actin cytoskeleton contractility of smooth muscle cells. Herein, we report that HGF induces actin cytoskeleton remodeling

Indexed as

actin cytoskeletonHGF/c-Metmyoid cellsTGF-βuPA

Identifiers

PMID28536401
PMCPMC5344232
OpenAlexW2088747981

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.