ReviewBiomedicines2017
New Insights into the Pathophysiology and Treatment of Fibromyalgia.
Review in Biomedicines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06226376 (The Effects of EXOPULSE Mollii Suit on Fibromyalgia Syndrome in Patients With Fibromyalgia), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of EXOPULSE Mollii Suit on Fibromyalgia Syndrome in Patients With Fibromyalgia (EXOFIB 2): A Sham Controlled Randomized Double-Blind Trial
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Optimal dose and type of exercise to reduce pain, anxiety and increase quality of life in patients with fibromyalgia. A systematic review with meta-analysis.Frontiers in physiology · 2023Pooled it
- The effects of EXOPULSE Mollii Suit in patients with fibromyalgia: a double-blind randomized sham-controlled trial (EXOFIB2).Pain medicine (Malden, Mass.) · 2026Trial
- The effect of the EXOPULSE Mollii Suit on pain and fibromyalgia-related symptoms-A randomized sham-controlled crossover trial.European journal of pain (London, England) · 2025Trial
- No effect of approved fibromyalgia drugs on the social pain (invalidation) contrary to physical pain: an open-label short-term randomized clinical trial.Clinical rheumatology · 2022Trial
- The effect of cryotherapy on fibromyalgia: a randomised clinical trial carried out in a cryosauna cabin.Rheumatology international · 2018Trial
- Molecular Hydrogen Reverses Nociplastic Pain and Depressive-like Behaviors via Region- and Sex-Dependent Central Mechanisms.International journal of molecular sciences · 2026Article
- The Influence of Rehabilitation Programs on the Mental State and Quality of Life in Patients with Fibromyalgia: A Comparative Cohort Study from Romania.International journal of environmental research and public health · 2025Article
- Three-Component Synthesis of γ-Amino Esters with α-Quaternary Carbon Centers via NHC/Photoredox Dual Catalysis.Advanced synthesis & catalysis · 2025Article
- Effects of Diathermy on Pain in Women with Fibromyalgia: A Randomized Controlled Trial.Biomedicines · 2024Article
- Unraveling the Complex Web of Fibromyalgia: A Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- Distinct neural signaling characteristics between fibromyalgia and provoked vestibulodynia revealed by means of functional magnetic resonance imaging in the brainstem and spinal cord.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Test-Retest Reliability of the Generalized Pain Questionnaire in Patients with Rheumatoid Arthritis and Preliminary Reference Values for Non-Clinical and Several Clinical Samples.Journal of pain research · 2023Article
- CNS imaging characteristics in fibromyalgia patients with and without peripheral nerve involvement.Scientific reports · 2022Article
- Distress as a mediator for pain and activities of daily living in older adults with fibromyalgia.Frontiers in medicine · 2022Article
- Central pain modulatory mechanisms of attentional analgesia are preserved in fibromyalgia.Pain · 2022Article
- Altered Pain in the Brainstem and Spinal Cord of Fibromyalgia Patients During the Anticipation and Experience of Experimental Pain.Frontiers in neurology · 2022Article
- Acupuncture modulates the frequency-specific functional connectivity density in primary dysmenorrhea.Frontiers in neuroscience · 2022Article
- Two sides on the fibromyalgia coin: physical pain and social pain (invalidation).Clinical rheumatology · 2021Review
- The Prevalence of Fibromyalgia Among Medical Students at King Abdulaziz University: A Cross-Sectional Study.Cureus · 2021Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibromyalgia is characterized by chronic widespread pain and several additional symptoms such as fatigue, cognitive dysfunction, depressive episodes, and anxiety. The underlying pathophysiology of fibromyalgia is still poorly understood, and treatment is often unsatisfactory. Current research provides evidence for altered pain processing in chronic pain patients, and specifically in fibromyalgia patients, possibly based on altered functional connectivity and brain chemistry in brain regions within the pain processing system. Besides discussing evidence from studies applying brain imaging (specifically resting state fMRI (Functional magnetic resonance imaging)), the current review aims at providing an overview of pharmacological and non-pharmacological treatment options. We will also summarize the most important results from recently performed brain imaging studies providing new insights into the potential mechanisms of various therapeutic approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.