Observational studyThe European respiratory journal2017
Improved outcomes in ex-smokers with COPD: a UK primary care observational cohort study.
Observational study in The European respiratory journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- All-Cause and Cause-Specific Mortality in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2025Pooled it
- Algorithms to identify COPD in health systems with and without access to ICD coding: a systematic review.BMC health services research · 2019Pooled it
- Impact of baseline symptoms and health status on COPD exacerbations in the FLAME study.Respiratory research · 2020Trial
- Association between Income, Neighborhood Vulnerability, and 5-Year Survival after Chronic Obstructive Pulmonary Disease Hospitalization in Medicare Beneficiaries.Annals of the American Thoracic Society · 2025Article
- The association of life's essential 8 with prevalence of chronic respiratory diseases in adults: insights from NHANES 2007-2018.BMC pulmonary medicine · 2025Article
- Methylation-based smoking signatures in blood and tissue samples for the prediction of self-reported smoking status and mortality in patients with colorectal cancer.Clinical epigenetics · 2025Article
- Impact of Smoking Cessation Duration on Exacerbation Readmission Frequency and Hospitalization Costs in COPD - Beijing Municipality, China, 2013-2021.China CDC weekly · 2025Article
- Characteristics and Outcomes of People With COPD Who Experience Exacerbations While on Inhaled Triple Therapy: Results of the SIRIUS I Cohort Study in the US (2015-2019).International journal of chronic obstructive pulmonary disease · 2025Observational
- Impact of Individual Characteristics on Hospital Outcomes in Exacerbated COPD in a Biomass-Exposed Turkish Population.Journal of clinical medicine · 2024Article
- COPD and Smoking Status - It Does Matter: Characteristics and Prognosis of COPD According to Smoking Status.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- Association of cigarette smoking with increased use of heated tobacco products in middle-aged and older adults with self-reported chronic obstructive pulmonary disease, asthma, and asthma-COPD overlap in Japan, 2022: the JASTIS study.BMC pulmonary medicine · 2023Article
- Challenges and perspectives of tobacco cessation in special groups of patients and populations.Breathe (Sheffield, England) · 2023Review
- Characteristics of Current Smokers versus Former Smokers with COPD and Their Associations with Smoking Cessation Within 4.5 Years: Results from COSYCONET.International journal of chronic obstructive pulmonary disease · 2023Article
- Predictors of Single Bronchodilation Treatment Response for COPD: An Observational Study with the Trace Database Cohort.Journal of clinical medicine · 2021Article
- COPD Clinical Control: predictors and long-term follow-up of the CHAIN cohort.Respiratory research · 2021Observational
- Smoking load reduction is insufficient to downregulate miR-301b, a lung cancer promoter.Scientific reports · 2020Article
- Reducing the Number of Hospitalization Days for COPD: Setting up a Transmural-Care Pathway.International journal of chronic obstructive pulmonary disease · 2020Article
- Different Characteristics of Ex-Smokers and Current Smokers with COPD: A Cross-Sectional Study in China.International journal of chronic obstructive pulmonary disease · 2020Article
- COPD overdiagnosis in primary care: a UK observational study of consistency of airflow obstruction.NPJ primary care respiratory medicine · 2019Observational
- Karma of Cardiovascular Disease Risk Factors for Prevention and Management of Major Cardiovascular Events in the Context of Acute Exacerbations of Chronic Obstructive Pulmonary Disease.Frontiers in cardiovascular medicine · 2019Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Smoking cessation in chronic obstructive pulmonary disease (COPD) reduces accelerated forced expiratory volume in 1 s decline, but impact on key health outcomes is less clear. We studied the relationship of smoking status to mortality and hospitalisation in a UK primary care COPD population.Using patient-anonymised routine data in the Hampshire Health Record Analytical Database, we identified a prevalent COPD cohort, categorising patients by smoking status (current, ex- or never-smokers). Three outcomes were measured over 3 years (2011-2013): all-cause mortality, respiratory-cause unplanned hospital admission and respiratory-cause emergency department attendance. Survival analysis using multivariable Cox regression after multiple imputation was used to estimate hazard ratios for each outcome by smoking status, adjusting for measured confounders (including age, lung function, socioeconomic deprivation, inhaled medication and comorbidities).We identified 16 479 patients with COPD, mean±sd age 70.1±11.1 years. Smoking status was known in 91.3%: 35.1% active smokers, 54.3% ex-smokers, 1.9% never-smokers. Active smokers predominated among younger patients. Compared with active smokers (n=5787), ex-smokers (n=8941) had significantly reduced risk of death, hazard ratio (95% confidence interval) 0.78 (0.70-0.87), hospitalisation, 0.82 (0.74-0.89) and emergency department attendance, 0.78 (0.70-0.88).After adjusting for confounders, ex-smokers had significantly better outcomes, emphasising the importance of effective smoking cessation support, regardless of age or lung function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.