Evidence map›Paper›PMID 28536226›Full record

ArticleBMJ case reports2017

Severe medication-induced peripheral neuropathy treated with topical doxepin cream in a paediatric patient with leukaemia.

Zephyr D Dworsky, Rebecca Bennett, Jenny M Kim, Dennis John Kuo

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zephyr D DworskyPediatrics, University of California, San Diego, California, USA.
Rebecca BennettAcute/Chronic Pain Service, Rady Children's Hospital - San Diego, San Diego, CA, USA.
Jenny M KimPediatric Hematology-Oncology, University of California, San Diego, California, USA.
Dennis John KuoPediatric Hematology-Oncology, University of California, San Diego, California, USA.ORCID http://orcid.org/0000-0003-4154-0057

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 17-year-old female with recently relapsed acute lymphoblastic leukaemia and a treatment course complicated by rhinocerebral mucormycosis infection developed severe peripheral neuropathy during the treatment for mucormycosis infection. This was felt to be a medication side effect. Her peripheral neuropathy was refractory to many well-established treatments, but ultimately responded dramatically and consistently to a novel therapy, topical doxepin cream (5%). This case report is the first published report of the application of topical doxepin cream for treatment of peripheral neuropathy in a paediatric patient.

Indexed as

Administration, TopicalAdolescentDosage FormsDoxepinFemaleHumansMucormycosisPeripheral Nervous System DiseasesPrecursor Cell Lymphoblastic Leukemia-LymphomaSeverity of Illness IndexDosage FormsDoxepinNeurology (drugs and medicines)Paediatric oncologyPeripheral nerve disease

Identifiers

PMID28536226
PMCPMC5753714

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.