Evidence map›Paper›PMID 28536147›Full record

ArticleGenes & development2017

Hormone-dependent control of developmental timing through regulation of chromatin accessibility.

Christopher M Uyehara, Spencer L Nystrom, Matthew J Niederhuber, Mary Leatham-Jensen, Yiqin Ma, Laura A Buttitta, Daniel J McKay

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 141 citations in OpenAlex.

  1. Article
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  7. bioRxiv : the preprint server for biology · 2025
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  8. Genomic and insulin-mediated control of metabolic homeostasis by the mosquito ecdysone-induced gene E93.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. 20E-inducedProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. E93 controls adult differentiation by repressingProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Chronologically inappropriate morphogenesis (Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
  16. Article
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Christopher M UyeharaDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
Spencer L NystromDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
Matthew J NiederhuberDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
Mary Leatham-JensenDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
Yiqin MaDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Laura A ButtittaDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Daniel J McKayDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA.ORCID 0000-0001-8226-0604
University of North Carolina at Chapel Hill · USUniversity of Michigan · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
NIGMS NIH HHS T32 GM007092NIH HHS P40 OD018537
6 · The paper itself

Abstract

Specification of tissue identity during development requires precise coordination of gene expression in both space and time. Spatially, master regulatory transcription factors are required to control tissue-specific gene expression programs. However, the mechanisms controlling how tissue-specific gene expression changes over time are less well understood. Here, we show that hormone-induced transcription factors control temporal gene expression by regulating the accessibility of DNA regulatory elements. Using the

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsChromatinDrosophilaDrosophila ProteinsEcdysoneEnhancer Elements, GeneticFemalePupaSignal TransductionTranscription FactorsWings, AnimalChromatinDrosophila ProteinsEcdysoneEip93F protein, DrosophilaTranscription Factorsecdysonegenomicsopen chromatinpioneer transcription factortemporal gene regulation

Identifiers

PMID28536147
PMCPMC5458754
OpenAlexW2619613145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.