ArticlePhysiological reports2017
Angiotensin converting enzyme 1 in the median preoptic nucleus contributes to chronic intermittent hypoxia hypertension.
Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Brain nitric oxide and inflammation in chronic intermittent hypoxia: Contributors to cognitive impairment and hypertension.Brain, behavior, & immunity - health · 2025Review
- Chronic intermittent hypoxia and ovariectomy exert independent and region-specific effects on ΔFosB expression and increase blood pressure in female rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Spontaneous and evoked angiotensin II sniffer cell activity in the lamina terminalis in vitro.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- AT1a-dependent GABAAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Role of angiotensin II in chronic intermittent hypoxia-induced hypertension and cognitive decline.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Review
- An Angiotensin-Responsive Connection from the Lamina Terminalis to the Paraventricular Nucleus of the Hypothalamus Evokes Vasopressin Secretion to Increase Blood Pressure in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Caspase lesions of PVN-projecting MnPO neurons block the sustained component of CIH-induced hypertension in adult male rats.American journal of physiology. Heart and circulatory physiology · 2020Article
- Glucocorticoid Receptor Antagonist Administration Prevents Adrenal Gland Atrophy in an ACTH-Independent Cushing's Syndrome Rat Model.International journal of endocrinology · 2019Article
- Chronic intermittent hypoxia induces hormonal and male sexual behavioral changes: Hypoxia as an advancer of aging.Physiology & behavior · 2018Article
- Effect of Chronic Intermittent Hypoxia on Angiotensin II Receptors in the Central Nervous System.Clinical and experimental hypertension (New York, N.Y. : 1993) · 2018Article
- Effect of Gender on Chronic Intermittent HypoxicFrontiers in physiology · 2018Article
- Angiotensin converting enzyme 1 in the median preoptic nucleus contributes to chronic intermittent hypoxia hypertension.Physiological reports · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Obstructive sleep apnea is associated with hypertension and cardiovascular disease. Chronic intermittent hypoxia is used to model the arterial hypoxemia seen in sleep apnea patients and is associated with increased sympathetic nerve activity and a sustained diurnal increase in blood pressure. The renin angiotensin system has been associated with hypertension seen in chronic intermittent hypoxia. Angiotensin converting enzyme 1, which cleaves angiotensin I to the active counterpart angiotensin II, is present within the central nervous system and has been shown to be regulated by AP-1 transcription factors, such as ΔFosB. Our previous study suggested that this transcriptional regulation in the median preoptic nucleus contributes to the sustained blood pressure seen following chronic intermittent hypoxia. Viral mediated delivery of a short hairpin RNA against angiotensin converting enzyme 1 in the median preoptic nucleus was used along with radio-telemetry measurements of blood pressure to test this hypothesis. FosB immunohistochemistry was utilized in order to assess the effects of angiotensin converting enzyme 1 knockdown on the activity of nuclei downstream from median preoptic nucleus. Angiotensin converting enzyme 1 knockdown within median preoptic nucleus significantly attenuated the sustained hypertension seen in chronic intermittent hypoxia. Angiotensin converting enzyme 1 seems to be partly responsible for regulating downstream regions involved in sympathetic and blood pressure control, such as the paraventricular nucleus and the rostral ventrolateral medulla. The data suggest that angiotensin converting enzyme 1 within median preoptic nucleus plays a critical role in the sustained hypertension seen in chronic intermittent hypoxia.
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