SynthesisCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2017
Relation of total sugars, fructose and sucrose with incident type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies.
Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph
Synthesis in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01608620 (The Relation of Total and Individual Fructose-containing Sugars With Incident Cardiometabolic Diseases), which is not on this map. Cited by 56 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 8 pooled it
8.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Relation of Total and Individual Fructose-containing Sugars With Incident Cardiometabolic Diseases: A Series of Systematic Reviews and Meta-analyses of Prospective Observational Studies
Who cites it
56 citing papers in PubMed, 8 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- The oral und systemic health risks of sugar consumption: an umbrella review.Clinical oral investigations · 2026Pooled it
- Ultra-Processed Food Intake and Risk of Type 2 Diabetes Mellitus: A Dose-Response Meta-Analysis of Prospective Studies.Diabetes & metabolism journal · 2025Pooled it
- Dietary Sugar Intake and Incident Type 2 Diabetes Risk: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.Advances in nutrition (Bethesda, Md.) · 2025Pooled it
- Dietary sugar consumption and health: umbrella review.BMJ (Clinical research ed.) · 2023Pooled it
- Fructose-containing food sources and blood pressure: A systematic review and meta-analysis of controlled feeding trials.PloS one · 2023Pooled it
- Important Food Sources of Fructose-Containing Sugars and Incident Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.Journal of the American Heart Association · 2019Pooled it
- Role of diet in type 2 diabetes incidence: umbrella review of meta-analyses of prospective observational studies.BMJ (Clinical research ed.) · 2019Pooled it
- Food sources of fructose-containing sugars and glycaemic control: systematic review and meta-analysis of controlled intervention studies.BMJ (Clinical research ed.) · 2018Pooled it
- Trial
- Trial
- Decreasing the RAG:SAG ratio of granola cereal predictably reduces postprandial glucose and insulin responses: a report of four randomised trials in healthy adults.Journal of nutritional science · 2022Trial
- Trial
- Free Sugars Consumption and Type 2 Diabetes: What Are the Concerns and How Strong is the Evidence?Current nutrition reports · 2026Review
- The association between high fructose corn syrup and the development of type-2 diabetes.Frontiers in clinical diabetes and healthcare · 2026Review
- Article
- Dietary carbohydrate intake and risk of type 2 diabetes: a 16-year prospective cohort study.Science China. Life sciences · 2025Article
- Association and substitution analyses of dietary sugars, starch and fiber for indices of body fat and cardiometabolic risk- a NoHoW sub-study.European journal of nutrition · 2025Article
- Types of dietary sugars and carbohydrates, cardiometabolic risk factors, and risk of diabetes: a cohort study from the general Danish population.Nutrition journal · 2025Article
- Validity of the Intake of Sugars, Amino Acids, and Fatty Acids Estimated Using a Self-administered Food Frequency Questionnaire in Middle-aged and Elderly Japanese: The Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT) Protocol Area.Journal of epidemiology · 2024Article
- Twenty-Four-Hour Urinary Sugars Biomarker in a Vending Machine Intake Paradigm in a Diverse Population.Nutrients · 2024Article
Corrections and comments
- Commented on by
Authors and funding
17 authors at 2 institutions in 2 countries.
Christine S TsilasToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
Russell J de SouzaToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
Sonia Blanco MejiaToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
Arash MirrahimiToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
Adrian I CozmaToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
Viranda H JayalathToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
Vanessa HaToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
Reem TawfikToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
Marco Di BuonoToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
Alexandra L JenkinsToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
Lawrence A LeiterToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
Thomas M S WoleverToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
Joseph BeyeneToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
Tauseef KhanToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
Cyril W C KendallToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
David J A JenkinsToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask.
John L SievenpiperToronto 3D Knowledge Synthesis and Clinical Trials Unit (Tsilas, de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Tawfik, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sievenpiper), Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ont.; Division of Food and Nutritional Sciences (Tsilas), Brescia University College at Western University, London, Ont.; Department of Nutritional Sciences (de Souza, Blanco Mejia, Mirrahimi, Cozma, Jayalath, Ha, Di Buono, A. Jenkins, Leiter, Wolever, Khan, Kendall, D. Jenkins, Sieven-piper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Health Research Methods, Evidence, and Impact (de Souza, Ha, Beyene), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; School of Medicine (Mirrahimi), Faculty of Health Sciences, Queen's University, Kingston, Ont.; MD Program (Cozma, Jayalath), Faculty of Medicine University of Toronto, Toronto, Ont.; Department of Medicine (Leiter, Wolever, D. Jenkins, Sievenpiper), Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Psychology (Tawfik), Faculty of Arts, University of Waterloo, Waterloo, Ont.; American Heart Association (Di Buono), Dallas, Tex.; Division of Endocrinology and Metabolism (Leiter, Wolever, D. Jenkins, Sievenpiper); Li Ka Shing Knowledge Institute (Leiter, Wolever, D. Jenkins, Sievenpiper), St. Michael's Hospital, Toronto, Ont.; Dalla Lana School of Public Health (Beyene), Faculty of Medicine, University of Toronto, Toronto, Ont.; College of Pharmacy and Nutrition (Kendall), University of Saskatchewan, Saskatoon, Sask. john.sievenpiper@utoronto.ca.
St Michael's Hospital · GBWestern University · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSugar-sweetened beverages are associated with type 2 diabetes. To assess whether this association holds for the fructose-containing sugars they contain, we conducted a systematic review and meta-analysis of prospective cohort studies.
methodsWe searched MEDLINE, Embase, CINAHL and the Cochrane Library (through June 2016). We included prospective cohort studies that assessed the relation of fructose-containing sugars with incident type 2 diabetes. Two independent reviewers extracted relevant data and assessed risk of bias. We pooled risk ratios (RRs) using random effects meta-analyses. The overall quality of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system.
resultsFiffeen prospective cohort studies (251 261 unique participants, 16 416 cases) met the eligibility criteria, comparing the highest intake (median 137, 35.2 and 78 g/d) with the lowest intake (median 65, 9.7 and 25.8 g/d) of total sugars, fructose and sucrose, respectively. Although there was no association of total sugars (RR 0.91, 95% confidence interval [CI] 0.76-1.09) or fructose (RR 1.04, 95% CI 0.84-1.29) with type 2 diabetes, sucrose was associated with a decreased risk of type 2 diabetes (RR 0.89, 95% CI 0.80-0.98). Our confidence in the estimates was limited by evidence of serious inconsistency between studies for total sugars and fructose, and serious imprecision in the pooled estimates for all 3 sugar categories.
interpretationCurrent evidence does not allow us to conclude that fructose-containing sugars independent of food form are associated with increased risk of type 2 diabetes. Further research is likely to affect our estimates.
trial registrationClinicalTrials.gov, no. NCT01608620.
Indexed as
BeveragesDiabetes Mellitus, Type 2Dietary SucroseFructoseHumansRisk AssessmentRisk FactorsSweetening AgentsDietary SucroseFructoseSweetening Agents
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Registered trials
NCT01608620ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.