ArticleJournal of lipid research2017
Effect of iron on cholesterol 7α-hydroxylase expression in alcohol-induced hepatic steatosis in mice.
Article in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Body Iron Stores and Metabolic Syndrome in Adults Free of Cardiometabolic Disease From Southwestern Colombia.Biological trace element research · 2026Article
- Non-Transferrin-Bound Iron in the Spotlight: Novel Mechanistic Insights into the Vasculotoxic and Atherosclerotic Effect of Iron.Antioxidants & redox signaling · 2021Review
- Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury.International journal of molecular sciences · 2021Article
- Quantification of common and planar bile acids in tissues and cultured cells.Journal of lipid research · 2020Article
- Long-term low-dose ethanol intake improves healthspan and resists high-fat diet-induced obesity in mice.Aging · 2020Article
- Integrated Multichip Analysis Identifies Potential Key Genes in the Pathogenesis of Nonalcoholic Steatohepatitis.Frontiers in endocrinology · 2020Article
- Iron overload reduces synthesis and elimination of bile acids in rat liver.Scientific reports · 2019Article
- Alcohol Induces More Severe Fatty Liver Disease by Influencing Cholesterol Metabolism.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Deficiency of cholesterol 7α-hydroxylase in bile acid synthesis exacerbates alcohol-induced liver injury in mice.Hepatology communications · 2018Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both iron and lipids are involved in the progression of alcoholic fatty liver disease (AFLD), but the interaction between iron and lipids in AFLD is unclear. Here, we tested the hypothesis that iron regulates the expression of genes involved in lipid metabolism through iron regulatory proteins (IRPs), which interact with the iron-responsive elements (IREs) in the untranslated regions (UTRs) of genes, resulting in lipid accumulation. Using "RNA structure software", we predicted the mRNA secondary structures of more than 100 genes involved in lipid metabolism to investigate whether the IRE structure exists in novel mRNAs. Cholesterol 7α-hydroxylase (
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Registered trials
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