ArticleMolecular brain2017
Turtle interacts with borderless in regulating glial extension and axon ensheathment.
Article in Molecular brain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- TheeLife · 2026Article
- Glia Regulate the Timing of Photoreceptor Differentiation in the Drosophila Visual System.Glia · 2026Article
- Review
- The exit of axons and glial membrane from the developing Drosophila retina requires integrins.Molecular brain · 2022Article
- Glial Tiling in the Insect Nervous System.Frontiers in cellular neuroscience · 2022Review
- Early lineage segregation of the retinal basal glia in the Drosophila eye disc.Scientific reports · 2020Article
- An RNAi screen for secreted factors and cell-surface players in coordinating neuron and glia development in Drosophila.Molecular brain · 2020Article
- The Conserved IgSF9 Protein Borderless Regulates Axonal Transport of Presynaptic Components and Color Vision inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Midline axon guidance in the Drosophila embryonic central nervous system.Seminars in cell & developmental biology · 2019Review
- Temporal and spatial order of photoreceptor and glia projections into optic lobe in Drosophila.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Proper recognition between axons and glial processes is required for the establishment of axon ensheathment in the developing nervous system. Recent studies have begun to reveal molecular events underlying developmental control of axon-glia recognition. In our previous work, we showed that the transmembrane protein Borderless (Bdl) is specifically expressed in wrapping glia (WG), and is required for the extension of glial processes and the ensheathment of photoreceptor axons in the developing Drosophila visual system. The exact mechanism by which Bdl mediates axon-glia recognition, however, remains unknown. Here, we present evidence showing that Bdl interacts with the Ig transmembrane protein Turtle (Tutl). Tutl is specifically expressed in photoreceptor axons. Loss of tutl in photoreceptors, like loss of bdl in WG, disrupts glial extension and axon ensheatment. Epistasis analysis shows that Tutl interacts genetically with Bdl. Tutl interacts with Bdl in trans in cultured cells. We propose that Tutl interacts with Bdl in mediating axon-glia recognition for WG extension and axon ensheathment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.