ArticleAmerican journal of hypertension2017
Antihypertensive Adherence Trajectories Among Older Adults in the First Year After Initiation of Therapy.
Article in American journal of hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Adherence to antihypertensives in the United States: A comparative meta-analysis of 23 million patients.Journal of clinical hypertension (Greenwich, Conn.) · 2024Pooled it
- Medication Adherence Trajectories: A Systematic Literature Review.Journal of managed care & specialty pharmacy · 2020Pooled it
- Effect of Electronic Health Record-Based Medication Support and Nurse-Led Medication Therapy Management on Hypertension and Medication Self-management: A Randomized Clinical Trial.JAMA internal medicine · 2018Trial
- Medication adherence trajectory and its impact on recurrent stroke after carotid artery stenting.Frontiers in neurology · 2025Article
- Review
- Clinical factors associated with patterns of endocrine therapy adherence in premenopausal breast cancer patients.Breast cancer research : BCR · 2024Article
- The Association between Deductibles and Cardiovascular Medication Adherence: A Retrospective Inception Cohort Study.Drugs - real world outcomes · 2024Article
- Rationale and performances of a data-driven method for computing the duration of pharmacological prescriptions using secondary data sources.Scientific reports · 2022Article
- Three Sides to the Story: Adherence Trajectories During the First Year of SGLT2 Inhibitor Therapy Among Medicare Beneficiaries.Diabetes care · 2022Article
- Assessing Concurrent Adherence to Combined Essential Medication and Clinical Outcomes in Patients With Acute Coronary Syndrome. A Population-Based, Real-World Study Using Group-Based Trajectory Models.Frontiers in cardiovascular medicine · 2022Article
- Comparing Continuous and Binary Group-based Trajectory Modeling Using Statin Medication Adherence Data.Medical care · 2021Article
- Article
- Opening the black box of the group-based trajectory modeling process to analyze medication adherence patterns: An example using real-world statin adherence data.Pharmacoepidemiology and drug safety · 2020Article
- Beyond Adherence Thresholds: A Simulation Study of the Optimal Classification of Longitudinal Adherence Trajectories From Medication Refill Histories.Frontiers in pharmacology · 2019Article
- Initiation of antihypertensive monotherapy and incident fractures among Medicare beneficiaries.Injury epidemiology · 2017Article
- Dispensing patterns of antidepressant and antianxiety medications for psychiatric disorders after benign hysterectomy in reproductive-age women: Results from group-based trajectory modeling.Women's health (London, England)Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundAdherence to antihypertensives is suboptimal, but previous methods of quantifying adherence fail to account for varying patterns of use over time. We sought to improve classification of antihypertensive adherence using group-based trajectory models, and to determine whether individual factors predict adherence trajectories.
methodsWe identified older adults initiating antihypertensive therapy during 2008-2011 using a 20% sample of Medicare (federal health insurance available to US residents over the age of 65) beneficiaries enrolled in parts A (inpatient services), B (outpatient services), and D (prescription medication). We developed monthly adherence indicators using prescription fill dates and days supply data in the 12 months following initiation. Adherence was defined as having at least 80% of days covered. Logistic models were used to identify trajectory groups. Bayesian information criterion and trajectory group size were used to select the optimal trajectory model. We compared the distribution of covariates across trajectory groups using multivariable logistic regression.
resultsDuring 2008-2011, 282,520 Medicare beneficiaries initiated antihypertensive therapy (mean age 75 years, 60% women, 84% White). Six trajectories were identified ranging from perfect adherence (12-month adherence of 0.97, 40% of beneficiaries) to immediate stopping (12-month adherence of 0.10, 18% of beneficiaries). The strongest predictors of nonadherence were initiation with a single antihypertensive class (adjusted odds ratio = 2.08 (95% confidence interval: 2.00-2.13)), Hispanic (2.93 (2.75-3.11)) or Black race/ethnicity (2.04 (1.95-2.13)), and no prior history of hypertension (2.04 (2.00-2.08)) (Area under the receiving operating characteristic curve: 0.53).
conclusionsThere is substantial variation in antihypertensive adherence among older adults. Certain patient characteristics are likely determinants of antihypertensive adherence trajectories.
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