ArticleInvestigative ophthalmology & visual science2017
Increased Retinal Oxygen Metabolism Precedes Microvascular Alterations in Type 1 Diabetic Mice.
Article in Investigative ophthalmology & visual science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.Journal of biomedical optics · 2022Pooled it
- Insights on Acute and Chronic Lacquer Cracks as Imaged with Visible Light OCT.Ophthalmology science · 2026Article
- Diabetes associated pericyte metabolic signatures and pathogenesis of diabetic retinopathy.Frontiers in endocrinology · 2026Review
- Racial Variations in Retinal Oxygen Metabolic Biomarkers in Diabetic Retinopathy: A Pilot Study.Journal of ophthalmology · 2026Article
- Quantifying retinal oxygenation and metabolism by phosphorescence lifetime imaging.Experimental eye research · 2025Review
- Visible Light Optical Coherence Tomography: Technology and Biomedical Applications.Bioengineering (Basel, Switzerland) · 2025Review
- Visible-light optical coherence tomography and its applications.Neurophotonics · 2025Review
- Oxygen profiles and oxygen consumption in the isolated mouse retina.Experimental eye research · 2023Article
- A case of choroidal melanocytosis observed by multimodal imaging with laser speckle flowgraphy.BMC ophthalmology · 2023Article
- Multiple forward scattering reduces the measured scattering coefficient of whole blood in visible-light optical coherence tomography.Biomedical optics express · 2022Article
- Retinal Oxygen Delivery and Extraction in Ophthalmologically Healthy Subjects With Different Blood Pressure Status.Translational vision science & technology · 2022Article
- The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques.Frontiers in medicine · 2022Review
- Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice.Scientific reports · 2021Article
- Integrated pancreatic microcirculatory profiles of streptozotocin-induced and insulin-administrated type 1 diabetes mellitus.Microcirculation (New York, N.Y. : 1994) · 2021Article
- Photoreceptor responses to light in the pathogenesis of diabetic retinopathy.Visual neuroscience · 2020Review
- Monitoring retinal responses to acute intraocular pressure elevation in rats with visible light optical coherence tomography.Neurophotonics · 2019Article
- Longitudinal deep-brain imaging in mouse using visible-light optical coherence tomography through chronic microprism cranial window.Biomedical optics express · 2019Article
- Longitudinal detection of retinal alterations by visible and near-infrared optical coherence tomography in a dexamethasone-induced ocular hypertension mouse model.Neurophotonics · 2019Article
- Article
- Designing visible-light optical coherence tomography towards clinics.Quantitative imaging in medicine and surgery · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Purpose: To investigate inner retinal oxygen metabolic rate (IRMRO2) during early stages of type 1 diabetes in a transgenic mouse model. Methods: In current study, we involved seven diabetic mice (Akita/+, TSP1-/-) and seven control mice (TSP1-/-), and applied visible-light optical coherence tomography (vis-OCT) to image functional parameters including retinal blood flow rate, oxygen saturation (sO2) and the IRMRO2 value longitudinally from 5 weeks of age to 13 weeks of age. After imaging at 13 weeks of age, we analyzed the imaging results, and examined histology of mouse retina. Results: Between diabetic mice and the control group, we observed significant differences in venous sO2 from 9 weeks of age (P = 0.006), and significant increment in IRMRO2 from 11 weeks of age (P = 0.001) in diabetic mice compared with control group. We did not find significant differences in retinal blood flow rate as well as arterial sO2 during imaging between diabetic and control mice. Histologic examination of diabetic and control mice at 13 weeks of age also revealed no anatomical retinal alternations. Conclusions: In diabetic retinopathy, complications in retinal oxygen metabolism may occur before changes of retinal anatomical structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.