Evidence map›Paper›PMID 28535253›Full record

ReviewNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2018

Endothelial glycocalyx-the battleground for complications of sepsis and kidney injury.

Jong Wook Song, Joseph Zullo, Mark Lipphardt, Matthew Dragovich, Frank X Zhang, Bingmei Fu, Michael S Goligorsky

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Effect of 5% albumin on endothelial glycocalyx degradation during off-pump coronary artery bypass.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024
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  17. Sirtuin 1 and endothelial glycocalyx.Pflugers Archiv : European journal of physiology · 2020
    Review
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  20. Glycocalyx breakdown is increased in African children with cerebral and uncomplicated falciparum malaria.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jong Wook SongRenal Research Institute, Departments of Medicine, Pharmacology and Physiology, New York Medical College at Touro University, Valhalla, NY, USA.
Joseph ZulloRenal Research Institute, Departments of Medicine, Pharmacology and Physiology, New York Medical College at Touro University, Valhalla, NY, USA.
Mark LipphardtRenal Research Institute, Departments of Medicine, Pharmacology and Physiology, New York Medical College at Touro University, Valhalla, NY, USA.
Matthew DragovichDepartment of Mechanical Engineering and Mechanics, and Bioengineering Program, Lehigh University, Bethlehem, PA, USA.
Frank X ZhangDepartment of Mechanical Engineering and Mechanics, and Bioengineering Program, Lehigh University, Bethlehem, PA, USA.
Bingmei FuDepartment of Biomedical Engineering, City College of the City University of New York, New York, USA.
Michael S GoligorskyRenal Research Institute, Departments of Medicine, Pharmacology and Physiology, New York Medical College at Touro University, Valhalla, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

After briefly discussing endothelial glycocalyx and its role in vascular physiology and renal disease, this overview focuses on its degradation very early in the course of microbial sepsis. We describe our recently proposed mechanism for glycocalyx degradation induced by exocytosis of lysosome-related organelles and release of their cargo. Notably, an intermediate in nitric oxide synthesis, NG-hydroxy-l-arginine, shows efficacy in curtailing exocytosis of these organelles and improvement in animal survival. These data not only depict a novel mechanism responsible for very early glycocalyx degradation, but may also outline a potential preventive therapy. The second issue discussed in this article is related to the therapeutic acceleration of restoration of already degraded endothelial glycocalyx. Here, using as an example our recent findings obtained with sulodexide, we illustrate the importance of the expedited repair of degraded endothelial glycocalyx for the survival of animals with severe sepsis. These two focal points of the review on glycocalyx may not only have broader disease applicability, but they may also provide additional evidence to buttress the idea of the importance of endothelial glycocalyx and its maintenance and repair in the prevention and treatment of an array of renal and nonrenal diseases.

Indexed as

AnimalsEndothelium, VascularGlycocalyxHumansKidney DiseasesSepsisendotheliumendotoxemialysosomesulodexide

Identifiers

PMID28535253
PMCPMC5837430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.