ArticleAmerican journal of epidemiology2017
Parental Age and Risk of Pediatric Cancer in the Offspring: A Population-Based Record-Linkage Study in California.
Article in American journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Risk factors for childhood brain tumours: A systematic review and meta-analysis of observational studies from 1976 to 2022.Cancer epidemiology · 2024Pooled it
- Parental Age and Childhood Lymphoma and Solid Tumor Risk: A Literature Review and Meta-Analysis.JNCI cancer spectrum · 2022Pooled it
- Area-Based Marginalization and Incidence of Childhood Cancer.JAMA network open · 2026Article
- Parental age and its influence on functional dependency and cognitive decline in older adults: a cohort analysis.Journal of health, population, and nutrition · 2026Article
- Phthalates measured at birth and risk of testicular cancer in adolescents and young adults.JNCI cancer spectrum · 2026Article
- Nationwide trends in childhood cancer incidence and survival in Iran: analysis of national cancer registry data, 2005-2014.BMC pediatrics · 2025Article
- Association between maternal cancer and the incidence of cancer in offspring.European journal of epidemiology · 2025Article
- Cancer Risk in Patients With Muscular Dystrophy and Myotonic Dystrophy: A Register-Based Cohort Study.Neurology · 2024Article
- The role of maternal age & birth order on the development of unilateral and bilateral retinoblastoma: a multicentre study.Eye (London, England) · 2023Article
- Outdoor artificial light at night, air pollution, and risk of childhood acute lymphoblastic leukemia in the California Linkage Study of Early-Onset Cancers.Scientific reports · 2023Article
- Assisted Reproductive Technology and Risk of Childhood Cancers.JAMA network open · 2022Article
- Birth characteristics and childhood leukemia in Switzerland: a register-based case-control study.Cancer causes & control : CCC · 2021Article
- Socioeconomic status and childhood central nervous system tumors in California.Cancer causes & control : CCC · 2021Article
- Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health.Reproductive biology and endocrinology : RB&E · 2020Review
- Air pollution exposure at the residence and risk of childhood cancers in Denmark: A nationwide register-based case-control study.EClinicalMedicine · 2020Article
- Spatial-Temporal Cluster Analysis of Childhood Cancer in California.Epidemiology (Cambridge, Mass.) · 2020Article
- Risk factors for childhood and adult primary brain tumors.Neuro-oncology · 2019Review
- Persistent epigenetic changes in adult daughters of older mothers.Epigenetics · 2019Article
- Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium.Cancer epidemiology · 2019Article
- Family-based germline sequencing in children with cancer.Oncogene · 2019Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Linking birth records and cancer registry data from California, we conducted a population-based study with 23,419 cases and 87,593 matched controls born during 1978-2009 to investigate the relationship of parental age to risk of pediatric cancer. Compared with children born to mothers aged 20-24 years, those born to mothers in older age groups had a 13%-36% higher risk of pediatric cancer; the odds ratio for each 5-year increase in maternal age was 1.06 (95% confidence interval (CI): 1.04, 1.09). For cancer diagnosed in children in age groups 0-14 years and 15-19 years, the odds ratios for each 5-year increase in maternal age were 1.05 (95% CI: 1.02, 1.07) and 1.14 (95% CI: 1.09, 1.19), respectively. Having an older father also conferred an increased risk, with an odds ratio for each 5-year increase of 1.03 (95% CI: 1.02, 1.05) for cancer diagnosed at ages 0-19 years and 1.03 (95% CI: 1.02, 1.05) for cancer diagnosed at ages 0-14 years. While advancing maternal age increased risk of leukemia and central nervous system tumors, older paternal age was not associated with risk of either type. Both maternal and paternal older ages were associated with risk of lymphoma. In this large, population-based record-linkage study, advancing parental age, especially advancing maternal age, was associated with higher pediatric cancer risk, with variations across types of cancer.
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