ArticleMolecular medicine reports2017
High‑throughput sequencing analyses of oral microbial diversity in healthy people and patients with dental caries and periodontal disease.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Study on the Mechanism of Nd:YAG Laser-Assisted Therapy on the Changes of Subgingival Flora in Periodontitis.Oral health & preventive dentistry · 2024Trial
- Bacterial contamination and diversity of dental unit waterlines across dental specialties, outlets and distinct times: heterotrophic bacteria counting and sequencing analysis.Journal of oral microbiology · 2026Article
- Mapping the oral microbiome in children with oral diseases using next-generation sequencing: a systematic review.Journal of oral microbiology · 2026Review
- Identification of cariogenic bacteria by click chemistry mediated polyethylene glycolized graphyne nanozymes.Mikrochimica acta · 2025Article
- Ethnicity-based analysis of supragingival plaque composition and dental health behaviours in healthy subjects without caries.Heliyon · 2024Article
- A comparative study of microbial changes in dental plaque before and after single- and multiappointment treatments in patients with severe early childhood caries.BMC oral health · 2024Article
- Oral microbiota imbalance: A predisposing factor for Henoch-Schönlein Purpura in children.Heliyon · 2024Article
- Heavy Ion Radiation Directly Induced the Shift of Oral Microbiota and Increased the Cariogenicity ofMicrobiology spectrum · 2023Article
- Oral microbial communities in 5-year-old children with versus without dental caries.BMC oral health · 2023Article
- Oral microbiota analyses of Saudi sickle cell anemics with dental caries.International dental journal · 2023Article
- Dental caries and their microbiomes in children: what do we do now?Journal of oral microbiology · 2023Review
- Effects of topical fluoride application on oral microbiota in young children with severe dental caries.Frontiers in cellular and infection microbiology · 2023Article
- The Treatment Efficiency and Microbiota Analysis ofInternational journal of molecular sciences · 2022Article
- Comparison of the Oral Microbiota Structure among People from the Same Ethnic Group Living in Different Environments.BioMed research international · 2022Article
- Microbiome of Saliva and Plaque in Children According to Age and Dental Caries Experience.Diagnostics (Basel, Switzerland) · 2021Article
- Machine Learning Study in Caries Markers in Oral Microbiota from Monozygotic Twin Children.Diagnostics (Basel, Switzerland) · 2021Article
- Relationship between dental and periodontal health status and the salivary microbiome: bacterial diversity, co-occurrence networks and predictive models.Scientific reports · 2021Article
- Diversity of Oral Microbiome of Women From Urban and Rural Areas of Indonesia: A Pilot Study.Frontiers in oral health · 2021Article
- High Fat Diet Dysbiotic Mechanism of Decreased Gingival Blood Flow.Frontiers in physiology · 2021Article
- Evaluation of the Treatment Effect ofMediators of inflammation · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recurrence of oral diseases caused by antibiotics has brought about an urgent requirement to explore the oral microbial diversity in the human oral cavity. In the present study, the high‑throughput sequencing method was adopted to compare the microbial diversity of healthy people and oral patients and sequence analysis was performed by UPARSE software package. The Venn results indicated that a mean of 315 operational taxonomic units (OTUs) was obtained, and 73, 64, 53, 19 and 18 common OTUs belonging to Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria and Fusobacteria, respectively, were identified in healthy people. Moreover, the reduction of Firmicutes and the increase of Proteobacteria in the children group, and the increase of Firmicutes and the reduction of Proteobacteria in the youth and adult groups, indicated that the age bracket and oral disease had largely influenced the tooth development and microbial development in the oral cavity. In addition, the traditional 'pathogenic bacteria' of Firmicutes, Proteobacteria and Bacteroidetes (accounted for >95% of the total sequencing number in each group) indicated that the 'harmful' bacteria may exert beneficial effects on oral health. Therefore, the data will provide certain clues for curing some oral diseases by the strategy of adjusting the disturbed microbial compositions in oral disease to healthy level.
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