ArticleGenetics and molecular biology
Teratogens: a public health issue - a Brazilian overview.
Article in Genetics and molecular biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Use of dipyrone during pregnancy and risk of congenital anomalies: a systematic review.European journal of clinical pharmacology · 2025Pooled it
- Impact of congenital anomalies on infant mortality in the 14th Health Region of Paraná, from 2010 to 2019.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2026Article
- Epidemiological surveillance in congenital anomalies and rare diseases in Brazil: present situation and future challenges.Journal of community genetics · 2025Review
- Perception of Quality of Life by Primary Caregivers of Children with Congenital Zika Syndrome: a Cross-Sectional Study.Maternal and child health journal · 2025Article
- Updating an Overview of Teratology.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Geographic distribution of live births and infant mortality from congenital anomalies in Brazil, 2012-2017.Journal of community genetics · 2021Article
- Teratogenic Genesis in Fetal Malformations.Cureus · 2021Review
- Self-Medication Among Pregnant Women: Prevalence and Associated Factors.Frontiers in pharmacology · 2021Article
- Congenital anomalies in Santa Catarina: case distribution and trends in 2010-2018.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2021Article
- Anticonvulsants and Chromatin-Genes Expression: A Systems Biology Investigation.Frontiers in neuroscience · 2020Article
- The Politics of Disease Epidemics: a Comparative Analysis of the SARS, Zika, and Ebola Outbreaks.Global social welfare : research, policy & practice · 2020Article
- From abortion-inducing medications to Zika Virus Syndrome: 27 years experience of the First Teratogen Information Service in Latin America.Genetics and molecular biology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital anomalies are already the second cause of infant mortality in Brazil, as in many other middle-income countries in Latin America. Birth defects are a result of both genetic and environmental factors, but a multifactorial etiology has been more frequently observed. Here, we address the environmental causes of birth defects - or teratogens - as a public health issue and present their mechanisms of action, categories and their respective maternal-fetal deleterious effects. We also present a survey from 2008 to 2013 of Brazilian cases involving congenital anomalies (annual average of 20,205), fetal deaths (annual average of 1,530), infant hospitalizations (annual average of 82,452), number of deaths of hospitalized infants (annual average of 2,175), and the average cost of hospitalizations (annual cost of $7,758). Moreover, we report on Brazilian cases of teratogenesis due to the recent Zika virus infection, and to the use of misoprostol, thalidomide, alcohol and illicit drugs. Special attention has been given to the Zika virus infection, now proven to be responsible for the microcephaly outbreak in Brazil, with 8,039 cases under investigation (from October 2015 to June 2016). From those cases, 1,616 were confirmed and 324 deaths occurred due to microcephaly complications or alterations on the central nervous system. Congenital anomalies impact life quality and raise costs in specialized care, justifying the classification of teratogens as a public health issue.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.