Evidence map›Paper›PMID 28534850›Full record

ArticleInternational journal of molecular sciences2017

Exploration of the Esophageal Mucosal Barrier in Non-Erosive Reflux Disease.

Nicolaas F Rinsma, Ricard Farré, Fred J Troost, Montserrat Elizalde, Daniel Keszthelyi, Zsuzsanna Helyes, Ad A Masclee, José M Conchillo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Nicolaas F RinsmaDivision of Gastroenterology-Hepatology, Department of Internal Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands. n.rinsma@maastrichtuniversity.nl.
Ricard FarréTranslational Research Center for Gastrointestinal Disorders, Catholic University Leuven, 3000 Leuven, Belgium. ricard.farre@kuleuven.be.
Fred J TroostDivision of Gastroenterology-Hepatology, Department of Internal Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands. f.troost@maastrichtuniversity.nl.
Montserrat ElizaldeDivision of Gastroenterology-Hepatology, Department of Internal Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands. m.elizalde@maastrichtuniversity.nl.
Daniel KeszthelyiDivision of Gastroenterology-Hepatology, Department of Internal Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands. daniel.keszthelyi@maastrichtuniversity.nl.
Zsuzsanna HelyesDepartment of Pharmacology and Pharmacotherapy, University of Pécs, 7623 Pécs, Hungary. zsuzsanna.helyes@aok.pte.hu.
Ad A MascleeDivision of Gastroenterology-Hepatology, Department of Internal Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands. a.masclee@mumc.nl.
José M ConchilloDivision of Gastroenterology-Hepatology, Department of Internal Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands. j.conchillo@mumc.nl.
Maastricht University · NLInstituto de Salud Carlos III · ESUniversity of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the absence of visible mucosal damage, it is hypothesized that the esophageal mucosal barrier is functionally impaired in patients with non-erosive reflux disease (NERD). The aim of the present study was to perform an exploratory analysis of the mucosal barrier in NERD compared to erosive esophagitis (EE) and controls. A second aim was to explore

conclusionsesophageal mucosal barrier function and

Indexed as

AdultAgedElectric ImpedanceEsophagitis, PepticEsophagusFemaleHeartburnHumansMaleMiddle AgedMucous MembranePermeabilityProspective StudiesTight Junction ProteinsTranscriptional ActivationTRPV Cation ChannelsTight Junction ProteinsTRPV1 protein, humanTRPV Cation Channelserosive esophagitisheartburnmucosal integritynon-erosive reflux diseasetransepithelial electrical resistanceTRPV1Ussing chamber

Identifiers

PMID28534850
PMCPMC5455000
OpenAlexW2614633122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.