ArticleeLife2017
Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt).
Open access · goldAbstract read
In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 70 citations in OpenAlex.
- The protocadherin-15-LHFPL5 tip link complex is a heterotetrameric assembly in hair cell stereocilia.Biophysical journal · 2026Article
- Tekt2 regulates hair cell development and function by maintaining normal kinocilium morphology in zebrafish.Frontiers in cell and developmental biology · 2026Article
- Research Progress on MET, Tip Link, and Stereocilia Complex with Special Reference to Zebrafish.International journal of molecular sciences · 2025Review
- Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function.Nucleic acids research · 2025Article
- Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.eLife · 2025Article
- Defects in Exosome Biogenesis Are Associated with Sensorimotor Defects in ZebrafishThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.bioRxiv : the preprint server for biology · 2024Article
- Sensory transduction in auditory hair cells-PIEZOs can't touch this.The Journal of general physiology · 2024Article
- Differentiation and functioning of the lateral line organ in zebrafish require Smpx activity.Scientific reports · 2024Article
- The structure of theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Transmembrane Channel-Like (Tmc) Subunits Contribute to Frequency Sensitivity in the Zebrafish Utricle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Single molecule studies of the native hair cell mechanosensory transduction complex.bioRxiv : the preprint server for biology · 2023Article
- Evaluating the association of biallelic OGDHL variants with significant phenotypic heterogeneity.Genome medicine · 2023Article
- Regionalized Protein Localization Domains in the Zebrafish Hair Cell Kinocilium.Journal of developmental biology · 2023Article
- A sensation for inflation: initial swim bladder inflation in larval zebrafish is mediated by the mechanosensory lateral line.The Journal of experimental biology · 2023Article
- A sensation for inflation: initial swim bladder inflation in larval zebrafish is mediated by the mechanosensory lateral line.bioRxiv : the preprint server for biology · 2023Article
- Mechanoelectrical transduction-related genetic forms of hearing loss.Current opinion in physiology · 2023Article
- Alone in a crowd: effect of a nonfunctional lateral line on expression of the social hormone parathyroid hormone 2.Biology open · 2022Article
- Article
- Mechanotransduction in mammalian sensory hair cells.Molecular and cellular neurosciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Timothy EricksonOregon Hearing Research Center and the Vollum Institute, Oregon Health and Science University, Portland, United States.ORCID 0000-0002-0910-2535
Clive P MorganOregon Hearing Research Center and the Vollum Institute, Oregon Health and Science University, Portland, United States.
Jennifer OltDepartment of Biomedical Science, University of Sheffield, Sheffield, United States.
Katherine HardyDepartment of Biomedical Science, University of Sheffield, Sheffield, United States.
Elisabeth Busch-NentwichWellcome Trust Sanger Institute, Cambridge, United Kingdom.ORCID 0000-0001-6450-744X
Reo MaedaOregon Hearing Research Center and the Vollum Institute, Oregon Health and Science University, Portland, United States.
Rachel ClemensOregon Hearing Research Center and the Vollum Institute, Oregon Health and Science University, Portland, United States.
Jocelyn F KreyOregon Hearing Research Center and the Vollum Institute, Oregon Health and Science University, Portland, United States.
Alex NechiporukDepartment of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, United States.
Peter G Barr-GillespieOregon Hearing Research Center and the Vollum Institute, Oregon Health and Science University, Portland, United States.ORCID 0000-0002-9787-5860
Walter MarcottiDepartment of Biomedical Science, University of Sheffield, Sheffield, United States.ORCID 0000-0002-8770-7628
Teresa NicolsonOregon Hearing Research Center and the Vollum Institute, Oregon Health and Science University, Portland, United States.ORCID 0000-0002-0873-1583
Oregon Health & Science University · USWellcome Sanger Institute · GB
Funding
Hair-Bundle ProteinsR01DC002368 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Peter Gordon Barr-Gillespie · 1994 to 2026
$11.3MPORTLAND AREA COMMUNICATION RESEARCH CORE CENTERP30DC005983 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI NUTTALL, ALFRED L · 2003 to 2017
$9.0MCharacterization of the Mechanotransduction complex in hair cellsR01DC013572 · NIDCD · STANFORD UNIVERSITY · PI NICOLSON, TERESA A · 2015 to 2019
$1.6MGenetic analyses of axon transport and microtubule dynamics in ZebrafishR01HD072844 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI NECHIPORUK, ALEX · 2012 to 2016
$1.6MIn vivo biotinylation for analysis of nuclear and protein dynamicsR01DC013531 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI NICOLSON, TERESA A · 2013 to 2017
$1.2MNICHD NIH HHS R01 HD072844NIDCD NIH HHS P30 DC005983NIDCD NIH HHS R01 DC002368NIDCD NIH HHS R01 DC013531NIDCD NIH HHS R01 DC013572Wellcome Trust 102892
Abstract
Transmembrane O-methyltransferase (
Indexed as
Mechanotransduction, CellularMethyltransferasesAnimalsDisease Models, AnimalHair Cells, AuditoryHearing Loss, SensorineuralMembrane ProteinsMutationZebrafishZebrafish ProteinsMembrane ProteinsMethyltransferasesTMC1 protein, zebrafishZebrafish Proteinsdeafnesshair cellsmechanotransductionneurosciencetomttransmembrane channel-like proteinszebrafish
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.