ArticlePharmaceutical biology2017
Wound healing activity of Pluchea indica leaf extract in oral mucosal cell line and oral spray formulation containing nanoparticles of the extract.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- A critical overview of challenging roles of medicinal plants in improvement of wound healing technology.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Pooled it
- Targeted repair of oral mucosal injury: emerging applications of biomaterials-based drug delivery systems.Journal of nanobiotechnology · 2026Review
- Micro and Nano Drug Delivery Systems for the Treatment of Oral Mucositis: A Review.Pharmaceutics · 2025Review
- Structural Analysis of Cardanol and Its Biological Activities on Human Keratinocyte Cells.Metabolites · 2025Article
- Unlocking the potential of flavonoid-infused drug delivery systems for diabetic wound healing with a mechanistic exploration.Inflammopharmacology · 2024Review
- Oral Wound Healing Potential ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Antioxidant, Anti-Inflammatory and Attenuating Intracellular Reactive Oxygen Species Activities ofGels (Basel, Switzerland) · 2023Article
- Potential of the Ethyl Acetate Fraction of Padina boergesenii as a Natural UV Filter in Sunscreen Cream FormulationLife (Basel, Switzerland) · 2023Article
- Ultraviolet Radiation Protective and Anti-Inflammatory Effects ofGels (Basel, Switzerland) · 2022Article
- Development of Jelly Loaded with Nanogel Containing Natural L-Dopa fromPharmaceutics · 2022Article
- Phytoconstituents and Pharmacological Activities of Indian Camphorweed (Molecules (Basel, Switzerland) · 2022Review
- Phytochemical Analysis, Antioxidant, and Wound Healing Activity ofMolecules (Basel, Switzerland) · 2022Article
- Effects of Quercetin and Curcumin Combination on Antibacterial, Antioxidant, In Vitro Wound Healing and Migration of Human Dermal Fibroblast Cells.International journal of molecular sciences · 2021Article
- High Efficiency In Vitro Wound Healing ofJournal of fungi (Basel, Switzerland) · 2021Article
- In Vitro Gingival Wound Healing Activity of Extracts fromPharmaceutics · 2021Article
- Anticancer Potential of Biogenic Silver Nanoparticles: A Mechanistic Study.Pharmaceutics · 2021Article
- Stability, permeation, and cytotoxicity reduction of capsicum extract nanoparticles loaded hydrogel containing wax gourd extract.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Article
- Comprehensive Chemical Profiling in the Ethanol Extract ofMolecules (Basel, Switzerland) · 2019Article
- Biosynthesized Silver Nanoparticle (AgNP) FromFrontiers in microbiology · 2019Article
- Oral Wound Healing Effects of Acai Berry Water Extracts in Rat Oral Mucosa.Toxicological research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextPluchea indica (L.) Less (Asteraceae) is an herb used as a traditional medicine for wound healing. The chemical compounds found in Pluchea indica leaves are phenolic acids, flavonoids, anthocyanins and carotenoids.
objectiveThis study investigates the effect of Pluchea indica leaf ethanol extract and its nanoparticles (NPs) on cytotoxicity, cell survival and migration of human oral squamous carcinoma cell line. MATERIALS AND
methodsCell viability was measured using MTT assay to assess the effect of Pluchea indica leaf extract and NPs (1-500 μg/mL) on cytotoxicity and cell survival. The effect of Pluchea indica leaf extract and NPs on cell migration was determined by scratch assay. The % relative migration was calculated after 24, 48 and 72 h of treatment.
resultsThe sizes of Pluchea indica leaf extract NPs were in a range of nanometers. NPs possessed negative charge with the polydispersity index (PDI) smaller than 0.3. After the treatment for 24, 48 and 72 h, Pluchea indica leaf extract had IC DISCUSSION AND
conclusionsNPs increased cytotoxicity of the Pluchea indica leaf extract, increased the migration of cells at low concentration and increased colloidal stability of the extract in an oral spray formulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.