Evidence map›Paper›PMID 28534516›Full record

ArticleOncogene2017

Transcriptional and posttranscriptional regulation of HOXA13 by lncRNA HOTTIP facilitates tumorigenesis and metastasis in esophageal squamous carcinoma cells.

C Lin, Y Wang, Y Wang, S Zhang, L Yu, C Guo, H Xu

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 149 citations in OpenAlex.

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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

C LinDepartment of the Engineering Research Center of Peptide Drug Discovery and Development, China Pharmaceutical University, Nanjing, China.
Y WangDepartment of the Engineering Research Center of Peptide Drug Discovery and Development, China Pharmaceutical University, Nanjing, China.
Y WangDepartment of the Engineering Research Center of Peptide Drug Discovery and Development, China Pharmaceutical University, Nanjing, China.
S ZhangDepartment of the Engineering Research Center of Peptide Drug Discovery and Development, China Pharmaceutical University, Nanjing, China.
L YuDepartment of the Engineering Research Center of Peptide Drug Discovery and Development, China Pharmaceutical University, Nanjing, China.
C GuoDepartment of the Engineering Research Center of Peptide Drug Discovery and Development, China Pharmaceutical University, Nanjing, China.
H XuDepartment of the Engineering Research Center of Peptide Drug Discovery and Development, China Pharmaceutical University, Nanjing, China.
China Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The long non-coding RNA, HOTTIP, has an important role in tumorigenesis. It is known that HOTTIP regulates HOX gene family; however, its regulatory mechanism in esophageal squamous cell carcinoma (ESCC) remains elusive. In this study, we investigated the role of HOTTIP in ESCC and observed that HOTTIP/HOXA13 was upregulated in ESCC and promoted cell proliferation and metastasis in vivo and in vitro. Interestingly, harboring a miR-30b-binding site, HOTTIP as a molecular sponge mainly regulated miR-30b level in the nucleus and modulated the repression of HOXA13 mediated by miR-30b in the cytoplasm, resulting in the positive HOTTIP/HOXA13 correlation. In addition, HOTTIP upregulated snail1 by competitively binding miR-30b, subsequently promoting epithelial-mesenchymal transition (EMT) and invasion. HOTTIP directly bound the adaptor protein WDR5 and drove histone H3 lysine 4 trimethylation and HOXA13 gene transcription in ESCC cells. In conclusion, our findings indicated that HOTTIP modulated HOXA13 at both the transcriptional and posttranscriptional levels in ESCC cells and HOTTIP-miR-30b-HOXA13 axis may serve as potential diagnostic markers or drug targets for ESCC therapies.

Indexed as

Cell Transformation, NeoplasticAnimalsCarcinogenesisCarcinoma, Squamous CellCell Line, TumorCell ProliferationEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleGene Expression Regulation, NeoplasticHeterograftsHomeodomain ProteinsHumansMiceMice, Inbred BALB CNeoplasm Metastasishomeobox protein HOXA13Homeodomain Proteinslong noncoding RNA HOTTIP, humanRNA, Long Noncoding

Identifiers

PMID28534516
OpenAlexW2620062688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.