ArticleAnnals of intensive care2017
Nasal high flow in management of children with status asthmaticus: a retrospective observational study.
Article in Annals of intensive care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03091504 (Evaluation on the Efficacy of Bronchodilator Nebulization Via High Flow Nasal Cannula), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation on the Efficacy of Bronchodilator Nebulization Via High Flow Nasal Cannula
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Interventions for escalation of therapy for acute exacerbations of asthma in children: an overview of Cochrane Reviews.The Cochrane database of systematic reviews · 2020Pooled it
- Comparison of the effects of high-flow nasal cannula and bilevel positive airway pressure treatments as respiratory physiotherapy interventions for children with asthma exacerbation: a randomized clinical trial.Einstein (Sao Paulo, Brazil) · 2024Trial
- Nasal High-flow Oxygen Versus Conventional Oxygen Therapy for Acute Severe Asthma Patients: A Pilot Randomized Controlled Trial.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2021Trial
- Comparing Respiratory Support Modalities in Pediatric Asthma Exacerbation-A Systematic Review and Meta-Analysis.Pediatric reports · 2026Review
- High-flow nasal cannula use for respiratory support in children for indications other than acute bronchiolitis.The Cochrane database of systematic reviews · 2026Article
- A matched analysis of the use of high flow nasal cannula for pediatric severe acute asthma.Pediatric pulmonology · 2024Article
- Small Airways Disease Affects Aerosol Deposition in Children with Severe Asthma: A Functional Respiratory Imaging Study.Journal of aerosol medicine and pulmonary drug delivery · 2024Article
- High-flow nasal cannula is an expensive and clunky placebo: myth or maxim?Breathe (Sheffield, England) · 2024Review
- High-flow humidified oxygen as an early intervention in children with acute severe asthma: a feasibility randomised controlled trial.ERJ open research · 2024Article
- Noninvasive Respiratory Support in Pediatric Critical Asthma: What to Start and Where to Go?Respiratory care · 2024Article
- Noninvasive Respiratory Support for Pediatric Critical Asthma: A Multicenter Cohort Study.Respiratory care · 2024Article
- High-Flow Humidified Oxygen as an Early Intervention in Children With Acute Severe Asthma: Protocol for a Feasibility Randomized Controlled Trial.JMIR research protocols · 2024Article
- High flow nasal cannula use is associated with increased hospital length of stay for pediatric asthma.Pediatric pulmonology · 2023Article
- Clinical review of high-flow nasal oxygen therapy in human and veterinary patients.Frontiers in veterinary science · 2023Review
- The efficacy of high-flow oxygen versus conventional oxygen for asthma control: a meta-analysis of randomized controlled studies.Postepy dermatologii i alergologii · 2022Article
- Heated Humidified High-Flow Nasal Cannula in Children: State of the Art.Biomedicines · 2022Review
- Treatment patterns and frequency of key outcomes in acute severe asthma in children: a Paediatric Research in Emergency Departments International Collaborative (PREDICT) multicentre cohort study.BMJ open respiratory research · 2022Article
- High-Flow Nasal Cannula Oxygen Therapy: Physiological Mechanisms and Clinical Applications in Children.Frontiers in medicine · 2022Review
- Management of Children with Acute Asthma Attack: A RAND/UCLA Appropriateness Approach.International journal of environmental research and public health · 2021Article
- Narrative review of practical aspects of aerosol delivery via high-flow nasal cannula.Annals of translational medicine · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma is the most common obstructive airway disease in children and adults. Nasal high flow (NHF) is a recent device that is now used as a primary support for respiratory distress. Several studies have reported use of NHF as a respiratory support in status asthmaticus; however, there are no data to recommend such practice. We therefore conducted this preliminary study to evaluate NHF therapy for children with status asthmaticus admitted to our PICU in order to prepare a multicentre randomized controlled study.
resultsBetween November 2009 and January 2014, 73 patients with status asthmaticus were admitted to the PICU, of whom 39 (53%) were treated with NHF and among these 10 (26%) presented severe acidosis at admission (pH < 7.30). Thirty-four less severe children (41%) were treated with standard oxygen. For one child (2.6%) NHF failed and was then switched to non-invasive ventilation. NHF was discontinued in another patient because of the occurrence of pneumothorax after 31 h with NHF; the patient was then switched to standard oxygen therapy. Mean ± SD heart rate (165 ± 21 vs. 141 ± 25/min, p < 0.01) and respiratory rate (40 ± 13 vs. 31 ± 8/min, p < 0.01) decreased significantly, and blood gas improved in the first 24 h. In the subgroup of patients with acidosis, median [IQR] pH increased significantly between hour 0 and 2 (7.25 [7.21-7.26] vs. 7.30 [7.27-7.33], p = 0.009) and median [IQR] pCO
conclusionThis retrospective study showed the feasibility and safety of NHF in children with severe asthma. Blood gas and clinical parameters were significantly improved during the first 24 h. NHF failed in only two patients, and none required invasive ventilation.
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Registered trials
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