ArticleAnnals of intensive care2017
Functional outcome of patients with prolonged hypoglycemic encephalopathy.
Article in Annals of intensive care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 25 citations in OpenAlex.
- Hypoglycemic Encephalopathy.Clinical case reports · 2026Article
- Hypoglycemic Encephalopathy in a Patient With Diabetes Mellitus: A Case Report.Case reports in neurological medicine · 2026Article
- Stuporous State in a Dog Following Ingestion of Chewing Gum Containing Xylitol Without Documented Hypoglycemia.Clinical case reports · 2025Article
- Article
- Determining Potential Risk Factors for Epilepsy in Children with Neonatal Hypoglycemia.Iranian journal of child neurology · 2025Article
- Prolonged Hypoglycemic Encephalopathy: A Case Report.Clinical case reports · 2024Article
- Sodium-glucose cotransporter 1/2 inhibition and risk of neurodegenerative disorders: A Mendelian randomization study.Brain and behavior · 2024Article
- Description and Outcome of Severe Hypoglycemic Encephalopathy in the Intensive Care Unit.Neurocritical care · 2023Article
- Left Hemiplegia Possibly Due to Glucose Reperfusion Injury after Recovery of Severe Hypoglycemia in a Woman with Type 2 Diabetes Mellitus.Internal medicine (Tokyo, Japan) · 2022Article
- Sodium-glucose cotransporter 2 inhibitors and neurological disorders: a scoping review.Therapeutic advances in chronic disease · 2022Article
- Predictors of consciousness improvement in patients with hypoglycemic encephalopathy.Frontiers in endocrinology · 2022Article
- Hypoglycemic encephalopathy caused by overdose of metformin in an adolescent.Chinese medical journal · 2020Article
- Risk Factors of Hypoglycemic Encephalopathy and Prolonged Hypoglycemia in Patients With Severe Hypoglycemia.Journal of clinical medicine research · 2019Article
- A multimodal approach using somatosensory evoked potentials for prognostication in hypoglycemic encephalopathy.Clinical neurophysiology practice · 2019Article
- A novel case of Bálint syndrome with hallucinatory palinopsia following hypoglycemic coma: opening new doors to the origin of palinopsia.Neurology perspectivesArticle
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Authors and funding
12 authors at 10 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the causes, clinical course and long-term outcome of comatose patients with prolonged hypoglycemic encephalopathy.
methodsIn a multicenter retrospective study conducted in patients hospitalized from July 1, 2004, to July 1, 2014, we investigated functional long-term prognosis and identified prognosis factors of patients admitted in an intensive care unit (ICU) with prolonged neurological manifestations related to hypoglycemia. Eligible patients were adults admitted to the ICU with a Glasgow Coma Score <8 due to hypoglycemia and persistent consciousness disorders after normalizing blood glucose levels. Patients with possible other causes of consciousness disorders, previous cognitive disorders, hypothermia <35 °C or circulatory arrest within 24 h after ICU admission, were excluded. Follow-up phone call was used to determine patients' functional outcome using modified Rankin Scale (mRS) at a minimum of 1-year follow-up with mRS 0-3 defining good and mRS 4-6 poor outcomes.
resultsForty-nine patients were included. Causes of hypoglycemia were various, mainly including insulin or oral antidiabetic drugs abuse (65%) and neuroendocrine carcinoma (16%). Twenty (41%) patients died in the ICU, two (4%) patients further died and nine (18%) patients had a poor outcome at long-term follow-up. Five patients discharged from the ICU with mRS > 3 improved enough to be in the good outcome group 1 year later. Twenty-two (45%) patients underwent therapeutic limitation, mainly related to no expected hope for improvement. On multivariate analysis, only low mRS prior to ICU admission (OR 2.6; 95% CI 1.1-6.3; P = 0.03) and normal brain imaging (OR 7.1; 95% CI 1.1-44; P = 0.03) were significantly predictive of a good outcome. All patients (n = 15) who remained hypoglycemic >480 min had a poor outcome.
conclusionPoor outcome was observed in about 60% of this population of hypoglycemic encephalopathy. However, some patients can recover satisfactorily over time.
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