Evidence map›Paper›PMID 28534130›Full record

ArticleDrug delivery and translational research2017

Tissue distribution and dermal drug determination of indomethacin transdermal-absorption patches.

Jingjing Ma, Ying Gao, Yinghua Sun, Dawei Ding, Qi Zhang, Bingjun Sun, Menglin Wang, Jin Sun, Zhonggui He

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Drug delivery and translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jingjing MaShenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.
Ying GaoShenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.
Yinghua SunShenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China. sunyinghua77@aliyun.com.
Dawei DingShenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.
Qi ZhangShenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.
Bingjun SunShenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.
Menglin WangShenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.
Jin SunShenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.
Zhonggui HeShenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.
Shenyang Pharmaceutical University · CN

Funding

National Science and Technology Major Project of the Ministry of Science and Technology of China 2014ZX09507001-009the Science and technology research project of Education Department of Liaoning Province L2013390
6 · The paper itself

Abstract

The tissue distribution and percutaneous drug absorption of indomethacin (IND) patches were studied using commercial IND as a comparison. The concentration of IND in skin, plasma, and muscle in mice was measured by LC-MS/MS, and the IND concentration in the dermis of rats was also monitored by microdialysis. After percutaneous administration, the "double-peak" phenomenon occurred in different tissues, and the IND concentration was ranked as skin first, followed by plasma and then muscle. In particular, skin acted as a reservoir for drug release, and the "secondary hump" in tissue distribution was attributed to the subsequent release of lipophilic IND in skin. It was concluded that examination of the tissue distribution and application of a microdialysis technique provided an effective means of evaluating indomethacin pharmacokinetics.

Indexed as

Administration, CutaneousAnimalsChromatography, LiquidIndomethacinMaleMiceMicrodialysisMusclesPlasmaSkinSkin AbsorptionTandem Mass SpectrometryTissue DistributionTransdermal PatchIndomethacinDermal microdialysisDouble peaksIndomethacin patchesTissue distributionTopical application

Identifiers

PMID28534130
OpenAlexW2619652143

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.