Evidence map›Paper›PMID 28534118›Full record

ArticleBasic research in cardiology2017

Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury.

Yihua Bei, Tianzhao Xu, Dongchao Lv, Pujiao Yu, Jiahong Xu, Lin Che, Avash Das, John Tigges, Vassilios Toxavidis, Ionita Ghiran and 5 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic research in cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 124 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 1 synthesis or guideline pooled it, 186 citations in OpenAlex.

  1. Telerehabilitation as a Therapeutic Exercise Tool versus Face-to-Face Physiotherapy: A Systematic Review.International journal of environmental research and public health · 2023
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  11. Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)-Enriched Extracellular Vesicles That Promote Angiogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Yihua BeiCardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.
Tianzhao XuCardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.
Dongchao LvCardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.
Pujiao YuDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
Jiahong XuDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
Lin CheDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
Avash DasCardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
John TiggesBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Vassilios ToxavidisBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Ionita GhiranBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Ravi ShahCardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Yongqin LiCardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.
Yuhui ZhangHeart Failure Care Unit, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Saumya DasCardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Junjie XiaoCardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China. junjiexiao@live.cn.
Shanghai University · CNBeth Israel Deaconess Medical Center · USHarvard University · USMassachusetts General Hospital · USTongji Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNTongji University · CN

Funding

Impact of circadian rhythm in obtaining reference profiles of exRNAs in healthy iU01HL126497 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GHIRAN, IONITA CALIN · 2014 to 2018
$3.3M
Plasma miRNA predictors of adverse mechanical and electrical remodeling after MIUH3TR000901 · NCATS · MASSACHUSETTS GENERAL HOSPITAL · PI DAS, SAUMYA, KWONG, RAYMOND Y · 2015 to 2017
$3.2M
Novel Role for Circulating extracellular RNAs in Human Heart FailureR01HL122547 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DAS, SAUMYA · 2015 to 2019
$2.1M
Myocardial tissue architecture in heart failure: implications on physiology and fitnessK23HL127099 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SHAH, RAVI · 2016 to 2019
$668k
NCATS NIH HHS UH3 TR000901NHLBI NIH HHS K23 HL127099NHLBI NIH HHS R01 HL122547NHLBI NIH HHS U01 HL126497
6 · The paper itself

Abstract

Extracellular vesicles (EVs) serve an important function as mediators of intercellular communication. Exercise is protective for the heart, although the signaling mechanisms that mediate this cardioprotection have not been fully elucidated. Here using nano-flow cytometry, we found a rapid increase in plasma EVs in human subjects undergoing exercise stress testing. We subsequently identified that serum EVs were increased by ~1.85-fold in mice after 3-week swimming. Intramyocardial injection of equivalent quantities of EVs from exercised mice and non-exercised controls provided similar protective effects against acute ischemia/reperfusion (I/R) injury in mice. However, injection of exercise-induced EVs in a quantity equivalent to the increase seen with exercise (1.85 swim group) significantly enhanced the protective effect. Similarly, treatment with exercise-induced increased EVs provided additional anti-apoptotic effect in H

Indexed as

Physical ExertionAnimalsApoptosisCalcium-Binding ProteinsCell LineDisease Models, AnimalExercise TestExtracellular Signal-Regulated MAP KinasesExtracellular VesiclesFlow CytometryHSP27 Heat-Shock ProteinsHumansMaleMice, Inbred C57BLMyocardial InfarctionMyocardial Reperfusion InjuryCalcium-Binding ProteinsExtracellular Signal-Regulated MAP KinasesHSP27 Heat-Shock ProteinsHspb1 protein, ratPdcd6ip protein, ratRab35 protein, ratrab GTP-Binding ProteinsExerciseExtracellular vesiclesIschemia–reperfusion injury

Identifiers

PMID28534118
PMCPMC5748384
OpenAlexW2617321540

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.