Evidence map›Paper›PMID 28534093›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2017

Quality of life among perinatally HIV-affected and HIV-unaffected school-aged and adolescent Ugandan children: a multi-dimensional assessment of wellbeing in the post-HAART era.

A K Nkwata, S K Zalwango, F N Kizza, J N Sekandi, J Mutanga, M Zhang, P M Musoke, A E Ezeamama

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Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

A K NkwataDepartment of Epidemiology and Biostatistics, The University of Georgia, Athens, GA, USA.
S K ZalwangoDirectorate of Public Health and Environment, Kampala Capital City Authority, Kampala, Uganda.
F N KizzaDivision of Health Protection, Office of HIV, Georgia Department of Public Health, Atlanta, GA, USA.
J N SekandiDepartment of Epidemiology and Biostatistics, The University of Georgia, Athens, GA, USA.
J MutangaDepartment of Epidemiology and Biostatistics, The University of Georgia, Athens, GA, USA.
M ZhangDepartment of Epidemiology and Biostatistics, The University of Georgia, Athens, GA, USA.
P M MusokeMakerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.
A E EzeamamaDepartment of Psychiatry, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA. amara.ezeamama@hc.msu.edu.
University of Georgia · USGeorgia Department of Public Health · USKampala Capital City Authority · UGMakerere University · UGMichigan State University · USMUJHU Research Collaboration · UG

Funding

International AIDS Society 327-EZEUniversity of Georgia Research Foundation 2523
6 · The paper itself

Abstract

objectiveTo examine quality of life (QOL) in perinatally HIV-infected (PHIV) or HIV-exposed uninfected (PHEU) vs. healthy HIV-unexposed uninfected (HUU) children during school-age/adolescence.

methodsPHIV infection was diagnosed via DNA PCR. Current HIV status was confirmed by HIV rapid diagnostic test. Three HIV groups were defined: PHIV, PHEU, and HUU. QOL was assessed with proxy and self-report versions of the PedsQL™ 4.0 instrument at 6-18 years of age. QOL scores ranged from zero (least QOL) to 100 (highest QOL) in the following dimensions: combined QOL inventory (CQOLI), multi-dimensional vigor (MDV), general wellbeing (GWB), present functioning, and general cognitive functioning (CF). Multivariable linear regression models estimated HIV-related percent differences (β) in QOL scores and 95% confidence intervals (CI).

findingsCompared to HUU CQOLI deficits ranged from 6.5 to 9.2% (95% CI -15.4, -1.6), GWB deficit ranged from 6.5 to 10.5% (95% CI -16.0, -1.3), MDV deficit ranged from 6.8 to 11.6% (95% CI -14.5, 0.9), and CF deficit ranged from 9.7 to 13.1% for PHIV children. QOL deficits of similar magnitude and direction in most domains were observed for PHIV compared to PHEU. However, self-reported indicators of GWB (β = -3.5; 95% CI -9.0, 2.0) and present functioning (β = 4.0; 95% CI -4.6, 12.5) were similar for PHIV compared to PHEU. QOL scores were generally similar for PHEU compared to HUU.

conclusionPHEU and HUU had similar QOL profile but PHIV predicted sustained deficits in multiple QOL domains. PHIV and PHEU children were similar with respect to general wellbeing and present functioning. Psychosocial and scholastic interventions in combination with HIV care are likely to improve QOL in PHIV.

Indexed as

AdolescentAntiretroviral Therapy, Highly ActiveBlack PeopleChildFemaleHIV InfectionsHumansMaleQuality of LifeUgandaAdolescenceHealthy unexposed uninfected controlsPerinatally acquired HIV infectionPerinatally HIV-exposed uninfectedQuality of lifeSchool-age

Identifiers

PMID28534093
OpenAlexW2617811518

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.