ArticleGastroenterology report2017
Renal dysfunction in cirrhosis: acute kidney injury and the hepatorenal syndrome.
Article in Gastroenterology report, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03675633 (Fractional Excretion of Urea), which is not on this map. Cited by 50 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fractional Excretion of Urea: an Excellent Simple Tool for the Differential Diagnosis of Acute Kidney Injury in Liver Cirrhosis
Who cites it
50 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Chinese guidelines on the management of ascites in cirrhosis : Chinese Society of Hepatology, Chinese Medical Association.Hepatology international · 2024Guideline
- Correlation of ammonia and blood laboratory parameters with hepatic encephalopathy: A systematic review and meta-analysis.PloS one · 2024Pooled it
- [Guidelines on the management of ascites in cirrhosis (2023 version)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023Guideline
- Impact of acute kidney injury on the risk of mortality in patients with cirrhosis: a systematic review and meta-analysis.Renal failure · 2022Pooled it
- Recommendations on the Diagnosis and Initial Management of Acute Variceal Bleeding and Hepatorenal Syndrome in Patients with Cirrhosis.Digestive diseases and sciences · 2019Guideline
- Urinary neutrophil gelatinase-associated lipocalin: a key biomarker for differentiating acute kidney injury and predicting short-term mortality in liver cirrhosis patients.Renal failure · 2026Observational
- Protective Arm of Renin-Angiotensin System: Evidence of Nephroprotective Effects Against Acute Kidney Injury.Acta physiologica (Oxford, England) · 2026Review
- Anti-Angiogenic Features of Endostatin in Obesity, Liver Fibrosis, and Hepatocellular Carcinoma.Biomedicines · 2026Review
- A method for characterizing disease progression from acute kidney injury to chronic kidney disease.Journal of biomedical informatics · 2025Article
- Development and validation of a predictive model for postoperative hepatic dysfunction in Stanford type A aortic dissection.Scientific reports · 2025Article
- Transition from acute kidney injury to chronic kidney disease in liver cirrhosis patients: Current perspective.World journal of nephrology · 2025Review
- Incidence and predictors of vancomycin nephrotoxicity and mortality in patients with chronic liver disease: a two-center retrospective cohort study.BMC infectious diseases · 2025Article
- Outcomes of Acute Pancreatitis in Patients With and Without Liver Cirrhosis: A Retrospective Analysis.Cureus · 2025Article
- Article
- Acute kidney injury in chronic liver disease: Causes and prevalence in a cross-sectional study.Bioinformation · 2025Article
- Efficacy of albumin use in decompensated cirrhosis and real-world adoption in Australia.JGH open : an open access journal of gastroenterology and hepatology · 2024Review
- Review
- Hepatic Venous Pressure Gradient Predicts Further Decompensation in Cirrhosis Patients with Acute Esophageal Variceal Bleeding.Diagnostics (Basel, Switzerland) · 2023Article
- Acute kidney injury in patients with acute-on-chronic liver failure: clinical significance and management.Kidney research and clinical practice · 2023Article
- Fecal and Urinary Adipokines as Disease Biomarkers.Biomedicines · 2023Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal dysfunction is a common complication of liver cirrhosis and of utmost clinical and prognostic relevance. Patients with cirrhosis are more prone to developing acute kidney injury (AKI) than the non-cirrhotic population. Pre-renal AKI, the hepatorenal syndrome type of AKI (HRS-AKI, formerly known as 'type 1') and acute tubular necrosis represent the most common causes of AKI in cirrhosis. Correct differentiation is imperative, as treatment differs substantially. While pre-renal AKI usually responds well to plasma volume expansion, HRS-AKI and ATN require different specific approaches and are associated with substantial mortality. Several paradigms, such as the threshold of 2.5 mg/dL for diagnosis of HRS-AKI, have recently been abolished and novel urinary biomarkers are being investigated in order to facilitate early and correct diagnosis and treatment of HRS-AKI and other forms of AKI in patients with cirrhosis. This review summarizes the current diagnostic criteria, as well as pathophysiologic and therapeutic concepts for AKI and HRS-AKI in cirrhosis.
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