ArticleFrontiers in immunology2017
Towards an Integrative Understanding of Diet-Host-Gut Microbiome Interactions.
Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Molecular basis of precision nutrition: Food components, microbiome-derived metabolites, and multi-omics modeling.Food chemistry. Molecular sciences · 2026Review
- Identification of intestinal microbial population structure ofMicrobiology spectrum · 2025Article
- Gut microbiota in multiple sclerosis and animal models.The FEBS journal · 2025Review
- Litter quality modulates changes in bacterial and fungal communities during the gut transit of earthworm species of different ecological groups.ISME communications · 2025Article
- NEMoE: a nutrition aware regularized mixture of experts model to identify heterogeneous diet-microbiome-host health interactions.Microbiome · 2023Article
- Microbiota is structured by gut regions, life stage, and diet in the Black Soldier Fly (Frontiers in microbiology · 2023Article
- Article
- Intersection of Diet and Exercise with the Gut Microbiome and Circulating Metabolites in Male Bodybuilders: A Pilot Study.Metabolites · 2022Article
- A Guide to Dietary Pattern-Microbiome Data Integration.The Journal of nutrition · 2022Review
- The impact of device-assisted therapies on the gut microbiome in Parkinson's disease.Journal of neurology · 2022Article
- Swiss Cohort & Biobank - The White Paper.Public health reviews · 2022Article
- Genome-Inferred Correspondence between Phylogeny and Metabolic Traits in the Wild Drosophila Gut Microbiome.Genome biology and evolution · 2021Article
- Characterization of the gut microbiome in wild rocky mountainsnails (Oreohelix strigosa).Animal microbiome · 2021Article
- The complexities of the diet-microbiome relationship: advances and perspectives.Genome medicine · 2021Review
- Starvation Alters Gut Microbiome in Black Soldier Fly (Diptera: Stratiomyidae) Larvae.Frontiers in microbiology · 2021Article
- Influence of Lab Adapted Natural Diet and Microbiota on Life History and Metabolic Phenotype ofMicroorganisms · 2020Article
- The new microbiology: cultivating the future of microbiome-directed medicine.American journal of physiology. Gastrointestinal and liver physiology · 2020Review
- How gut microbiome interactions affect nutritional traits ofThe Journal of experimental biology · 2020Article
- Exploring the Bacterial Impact on Cholesterol Cycle: A Numerical Study.Frontiers in microbiology · 2020Article
- Complete genome sequence of acetate-producing3 Biotech · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last 20 years, a sizeable body of research has linked the microbiome and host diet to a remarkable diversity of diseases. Yet, unifying principles of microbiome assembly or function, at levels required to rationally manipulate a specific individual's microbiome to their benefit, have not emerged. A key driver of both community composition and activity is the host diet, but diet-microbiome interactions cannot be characterized without consideration of host-diet interactions such as appetite and digestion. This becomes even more complex if health outcomes are to be explored, as microbes engage in multiple interactions and feedback pathways with the host. Here, we review these interactions and set forth the need to build conceptual models of the diet-microbiome-host axes that draw out the key principles governing this system's dynamics. We highlight how "units of response," characterizations of similarly behaving microbes, do not correlate consistently with microbial sequence relatedness, raising a challenge for relating high-throughput data sets to conceptual models. Furthermore, they are question-specific; responses to resource environment may be captured at higher taxonomic levels, but capturing microbial products that depend on networks of different interacting populations, such as short-chain fatty acid production through anaerobic fermentation, can require consideration of the entire community. We posit that integrative approaches to teasing apart diet-microbe-host interactions will help bridge between experimental data sets and conceptual models and will be of value in formulating predictive models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.