ReviewFrontiers in physiology2017
Multiscale Modeling of Bone Healing: Toward a Systems Biology Approach.
Review in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Capturing the Multiscale Nature of Bone Behavior: Classical, Data-Driven and Hybrid Techniques.Annals of biomedical engineering · 2026Review
- In Silico possibilities to understand peri-implant bone healing- state of the Art.International journal of implant dentistry · 2025Review
- Computational modelling of bone growth and mineralization surrounding biodegradable Mg-based and permanent Ti implants.Computational and structural biotechnology journal · 2025Article
- On the influence of structural and chemical properties on the elastic modulus of woven bone under healing.Frontiers in bioengineering and biotechnology · 2024Article
- A Novel Computational Biomechanics Framework to Model Vascular Mechanopropagation in Deep Bone Marrow.Advanced healthcare materials · 2023Article
- COMMBINI: an experimentally-informed COmputational Model of Macrophage dynamics in the Bone INjury Immunoresponse.Frontiers in immunology · 2023Article
- Carbon Quantum Dots for Stem Cell Imaging and Deciding the Fate of Stem Cell Differentiation.ACS omega · 2022Review
- Computer-assisted preoperative planning of bone fracture fixation surgery: A state-of-the-art review.Frontiers in bioengineering and biotechnology · 2022Review
- Biomechanical models: key considerations in study design.OTA international : the open access journal of orthopaedic trauma · 2021Article
- TowardsFrontiers in bioengineering and biotechnology · 2021Review
- A Coupled Mechanobiological Model of Muscle Regeneration In Cerebral Palsy.Frontiers in bioengineering and biotechnology · 2021Article
- [Numerical simulation of fracture healing].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- Modeling the Human Bone-Tumor Niche: Reducing and Replacing the Need for Animal Data.JBMR plus · 2020Review
- Three-dimensional computational model simulating the fracture healing process with both biphasic poroelastic finite element analysis and fuzzy logic control.Scientific reports · 2018Article
- Evidence for Ongoing Modeling-Based Bone Formation in Human Femoral Head TrabeculaeFrontiers in endocrinology · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone is a living part of the body that can, in most situations, heal itself after fracture. However, in some situations, healing may fail. Compromised conditions, such as large bone defects, aging, immuno-deficiency, or genetic disorders, might lead to delayed or non-unions. Treatment strategies for those conditions remain a clinical challenge, emphasizing the need to better understand the mechanisms behind endogenous bone regeneration. Bone healing is a complex process that involves the coordination of multiple events at different length and time scales. Computer models have been able to provide great insights into the interactions occurring within and across the different scales (organ, tissue, cellular, intracellular) using different modeling approaches [partial differential equations (PDEs), agent-based models, and finite element techniques]. In this review, we summarize the latest advances in computer models of bone healing with a focus on multiscale approaches and how they have contributed to understand the emergence of tissue formation patterns as a result of processes taking place at the lower length scales.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.