ReviewFrontiers in neuroscience2017
Genetics of Tinnitus: Still in its Infancy.
Review in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Modifiable risk factors for tinnitus: A Mendelian randomization study.The Journal of international medical research · 2026Pooled it
- Pooled it
- Interactive Effects of Occupational Hearing Loss and Glutathion S-Transferase M1 Genotype on Tinnitus Among Noise-exposed Steelworkers.Safety and health at work · 2026Article
- Prevalence and associated risk factors of tinnitus among Palestinian adolescents aged 15-18: A cross-sectional study.PloS one · 2026Article
- The Role of Genetic and Non-Genetic Factors in the Occurrence of Cisplatin-Associated Ototoxicity.International journal of molecular sciences · 2025Review
- DNA Methylation Patterns Associated with Tinnitus in Young Adults-A Pilot Study.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Tinnitus prevalence and associated risk factors among university students: A cross-sectional study.SAGE open medicine · 2024Article
- Predicting Hearing Loss in Testicular Cancer Patients after Cisplatin-Based Chemotherapy.Cancers · 2023Article
- Targeting the Limbic System: Insights into Its Involvement in Tinnitus.International journal of molecular sciences · 2023Review
- Effects of Red and Infrared Laser Therapy in Patients with Tinnitus: A Double-Blind, Clinical, Randomized Controlled Study Combining Light with Ultrasound, Drugs and Vacuum Therapy.Journal of personalized medicine · 2023Article
- A genome-wide association study of tinnitus reveals shared genetic links to neuropsychiatric disorders.Scientific reports · 2022Article
- Association of Chronic Kidney Disease with Prior Tinnitus: A Case-Control Study.Journal of clinical medicine · 2022Article
- The Road Traveled and Journey Ahead for the Genetics and Genomics of Tinnitus.Molecular diagnosis & therapy · 2022Article
- [Research progress in auditory center plasticity and tinnitus mechanism].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Review
- Genetic predisposition to tinnitus in the UK Biobank population.Scientific reports · 2021Article
- Genome-wide association study identifies new loci associated with noise-induced tinnitus in Chinese populations.BMC genomic data · 2021Article
- The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis.Communications biology · 2021Article
- Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study.EBioMedicine · 2021Article
- Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank.Scientific reports · 2021Article
- Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers.Frontiers in aging neuroscience · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tinnitus is the perception of a phantom sound that affects between 10 and 15% of the general population. Despite this considerable prevalence, treatments for tinnitus are presently lacking. Tinnitus exhibits a diverse array of recognized risk factors and extreme clinical heterogeneity. Furthermore, it can involve an unknown number of auditory and non-auditory networks and molecular pathways. This complex combination has hampered advancements in the field. The identification of specific genetic factors has been at the forefront of several research investigations in the past decade. Nine studies have examined genes in a case-control association approach. Recently, a genome-wide association study has highlighted several potentially significant pathways that are implicated in tinnitus. Two twin studies have calculated a moderate heritability for tinnitus and disclosed a greater concordance rate in monozygotic twins compared to dizygotic twins. Despite the more recent data alluding to genetic factors in tinnitus, a strong association with any specific genetic locus is lacking and a genetic study with sufficient statistical power has yet to be designed. Future research endeavors must overcome the many inherent limitations in previous study designs. This review summarizes the previously embarked upon tinnitus genetic investigations and summarizes the hurdles that have been encountered. The identification of candidate genes responsible for tinnitus may afford gene based diagnostic approaches, effective therapy development, and personalized therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.