ArticleEuropean journal of organic chemistry2017
Local Desymmetrization through Diastereotopic Group Selection: An Enabling Strategy for Natural Product Synthesis.
Article in European journal of organic chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Enantioselective desymmetrization strategy of prochiral 1,3-diols in natural product synthesis.Beilstein journal of organic chemistry · 2025Review
- Asymmetric Synthesis of Chiral 2-Cyclohexenones with Quaternary Stereocenters via Ene-Reductase Catalyzed Desymmetrization of 2,5-Cyclohexadienones.ACS catalysis · 2024Article
- Absence of Intermediates in the BINOL-Derived Mg(II)/Phosphate-Catalyzed Desymmetrizative Ring Expansion of 1-Vinylcyclobutanols.The Journal of organic chemistry · 2022Article
- Article
- Regiodivergent Photocyclization of Dearomatized Acylphloroglucinols: Asymmetric Syntheses of (-)-Nemorosone and (-)-6-Journal of the American Chemical Society · 2019Article
- Asymmetric Organocatalytic Sulfa-Michael Addition to Enone Diesters.The Journal of organic chemistry · 2018Article
- Enantio- and Diastereoselective Organocatalytic Conjugate Additions of Nitroalkanes to Enone Diesters.Organic letters · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The application of desymmetrization strategies in chemical synthesis has allowed fundamentally new synthetic sequences that efficiently create dense and polyfunctional stereochemical arrays. Enantiotopic group discrimination has become a well-established method of global desymmetrization, while the conceptually unique strategy of local desymmetrization by diastereotopic group discrimination has its own advantages. This microreview focuses on the application of local desymmetrization in natural product synthesis and places a particular emphasis on the efficiency engendered by diastereotopic group discrimination. Local desymmetrization is subdivided into three distinct manifolds; examples under each paradigm are presented and compared.
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