ArticlePharmacogenomics and personalized medicine2017
DNA methylation at the mu-1 opioid receptor gene (
Article in Pharmacogenomics and personalized medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Role of microRNAs in the pathophysiology of addiction.Wiley interdisciplinary reviews. RNA · 2021Pooled it
- Systematic Review and Meta-Analysis of Genetic Risk of Developing Chronic Postsurgical Pain.The journal of painPooled it
- Chronic postsurgical pain in children: Current evidence and clinical perspectives.World journal of clinical pediatrics · 2026Review
- Heroin addiction modulates transcription factor binding in regulatory regions of the human putamen.Scientific reports · 2026Article
- Genetic and epigenetic insights into perioperative neurocognitive disorders: a narrative review.British journal of anaesthesia · 2026Review
- Hypermethylation of OPRM1: Deregulation of the Endogenous Opioid Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia.International journal of molecular sciences · 2026Article
- Presurgical Prognostic Factors for Chronic Postsurgical Pain Across Developmental Stages in Children, Adolescents, and Young Adults: A Systematic Review and Meta-Analysis.Journal of pain research · 2026Review
- Personalized Perioperative Opioid Strategies in Children: Focus on Methadone, Pharmacogenomics and Prevention of Persistent Postoperative Opioid Use.Children (Basel, Switzerland) · 2025Review
- Review
- Repetitive neonatal pain increases spinal cord DNA methylation of the µ-opioid receptor.Pediatric research · 2025Article
- Chronic postsurgical pain in young children: Prevalence, pain trajectories and physical and psychological prognostic factors.The journal of pain · 2025Observational
- Sex differences in the transition to chronic pain.The Journal of clinical investigation · 2025Review
- Observational
- Personalized Approaches to Spine Surgery.International journal of spine surgery · 2024Article
- Epigenetic Landscapes of Pain: DNA Methylation Dynamics in Chronic Pain.International journal of molecular sciences · 2024Review
- Risk Factors for Acute Postsurgical Pain: A Narrative Review.Journal of pain research · 2024Review
- Chronic Postsurgical Pain in Children and Adolescents: A Call for Action.Journal of pain research · 2024Review
- Current Evidence for Biological Biomarkers and Mechanisms Underlying Acute to Chronic Pain Transition across the Pediatric Age Spectrum.Journal of clinical medicine · 2023Article
- Sex Differences in Opioid Response Linked toJournal of clinical medicine · 2023Article
- Development and expansion of a pediatric transitional pain service to prevent complex chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
introductionThe perioperative pain experience shows great interindividual variability and is difficult to predict. The mu-1 opioid receptor gene (
methodsA prospective observational cohort study was conducted in 133 adolescents with idiopathic scoliosis undergoing spine fusion under standard protocols. Data regarding pain, opioid consumption, anxiety, and catastrophizing (using validated questionnaires) were collected before and 2-3 months postsurgery. Outcomes evaluated were preoperative pain, acute postoperative pain (area under curve [AUC] for pain scores over 48 hours), and CPSP (numerical rating scale >3/10 at 2-3 months postsurgery). Blood samples collected preoperatively were analyzed for DNA methylation by pyrosequencing of 22 CpG sites at the
resultsMajority (83%) of the patients reported no pain preoperatively, while CPSP occurred in 36% of the subjects (44/121). Regression on dichotomized preoperative pain outcome showed association with methylation at six CpG sites (1, 3, 4, 9, 11, and 17) ( DISCUSSION: Novel CPSP biomarkers were identified in an active regulatory region of the
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.