Evidence map›Paper›PMID 28533659›Full record

ArticleWorld journal of gastroenterology2017

BRAF inhibitor treatment of melanoma causing colonic polyps: An alternative hypothesis.

Fergal C Kelleher, Grainne Callaghan, Catriona Gallagher, Hazel O'Sullivan

Open access · greenAbstract read
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Fergal C KelleherFergal C Kelleher, Department of Medical Oncology, Specialty Certification Medical Oncology Royal College of Physicians United Kingdom, European Certification in Medical Oncology, The Adelaide and Meath Hospital, 24 Dublin, Ireland.
Grainne CallaghanFergal C Kelleher, Department of Medical Oncology, Specialty Certification Medical Oncology Royal College of Physicians United Kingdom, European Certification in Medical Oncology, The Adelaide and Meath Hospital, 24 Dublin, Ireland.
Catriona GallagherFergal C Kelleher, Department of Medical Oncology, Specialty Certification Medical Oncology Royal College of Physicians United Kingdom, European Certification in Medical Oncology, The Adelaide and Meath Hospital, 24 Dublin, Ireland.
Hazel O'SullivanFergal C Kelleher, Department of Medical Oncology, Specialty Certification Medical Oncology Royal College of Physicians United Kingdom, European Certification in Medical Oncology, The Adelaide and Meath Hospital, 24 Dublin, Ireland.
Northland District Health Board · NZRoyal College of Physicians · GBTallaght University Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colonic polyps may arise from BRAF inhibitor treatment of melanoma, possibly due to paradoxical activation of the mitogen-activated protein (MAP)-kinase pathway. In an alternative evidence based scenario, tubular colonic adenomas with

Indexed as

Adenomatous Polyposis Coli ProteinAdenomatous PolypsCellular SenescenceColonic PolypsColorectal NeoplasmsCpG IslandsDNA MethylationEpigenesis, GeneticHumansMAP Kinase Signaling SystemMelanomaMitogen-Activated Protein KinasesMutationMutL Protein Homolog 1Protein MultimerizationProto-Oncogene Proteins B-rafAdenomatous Polyposis Coli ProteinAPC protein, humanBRAF protein, humanMitogen-Activated Protein KinasesMLH1 protein, humanMutL Protein Homolog 1Proto-Oncogene Proteins B-rafProto-Oncogene Proteins c-rafBRAF inhibitorsColonic polypsMalignant melanomaSerrated polyps

Identifiers

PMID28533659
PMCPMC5423039
OpenAlexW2610281631

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.