Evidence map›Paper›PMID 28533516›Full record

ArticleMolecular psychiatry2018

ASD restricted and repetitive behaviors associated at 17q21.33: genes prioritized by expression in fetal brains.

R M Cantor, L Navarro, H Won, R L Walker, J K Lowe, D H Geschwind

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Characterizing the autism spectrum phenotype in DYRK1A-related syndrome.Autism research : official journal of the International Society for Autism Research · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Drug development for Autism Spectrum Disorder (ASD): Progress, challenges, and future directions.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2021
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

R M CantorDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
L NavarroDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
H WonNeurogenetics Program, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
R L WalkerNeurogenetics Program, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
J K LoweNeurogenetics Program, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
D H GeschwindDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

Autism Genetics, Phase II: Increasing Representation of Human DiversityR01MH100027 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2013 to 2024
$31.7M
2/3 Integrative Genomic Analysis of Human Brain Development and AutismR01MH110927 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2016 to 2019
$2.7M
Connecting gene regulatory mechanisms in human brain to psychiatric illnessR00MH113823 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WON, HYEJUNG · 2018 to 2020
$719k
Connecting gene regulatory mechanisms in human brain to psychiatric illnessK99MH113823 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WON, HYEJUNG · 2017 to 2017
$115k
NIMH NIH HHS K99 MH113823NIMH NIH HHS R00 MH113823NIMH NIH HHS R01 MH100027NIMH NIH HHS R01 MH110927
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a behaviorally defined condition that manifests in infancy or early childhood as deficits in communication skills and social interactions. Often, restricted and repetitive behaviors (RRBs) accompany this disorder. ASD is polygenic and genetically complex, so we hypothesized that focusing analyses on intermediate core component phenotypes, such as RRBs, can reduce genetic heterogeneity and improve statistical power. Applying this approach, we mined Caucasian genome-wide association studies (GWAS) data from two of the largest ASD family cohorts, the Autism Genetics Resource Exchange and Autism Genome Project (AGP). Of the 12 RRBs measured by the Autism Diagnostic Interview-Revised, seven were found to be significantly familial and substantially variable, and hence, were tested for genome-wide association in 3104 ASD-affected children from 2045 families. Using a stringent significance threshold (P<7.1 × 10

Indexed as

Chromosomes, Human, Pair 17AdolescentAdultAutism Spectrum DisorderBrainChildChild, PreschoolCompulsive BehaviorFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGestational AgeHomeodomain ProteinsHumansMaleMiddle AgedCALCOCO2 protein, humanDistal-less homeobox proteinsHomeodomain ProteinsMonosaccharide Transport ProteinsNuclear ProteinsPHB protein, humanProhibitinsRepressor ProteinsTranscription FactorsUDP-Galactose Translocators

Identifiers

PMID28533516
PMCPMC5700871
OpenAlexW2619172669

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.