ArticleScientific reports2017
Identification of genetic loci shared between schizophrenia and the Big Five personality traits.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.Nature human behaviour · 2024Pooled it
- Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.Nature genetics · 2018Pooled it
- Self-harming behavior linked to earlier onset of cardiovascular disease in severe mental disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- A Genome-Wide Association Study of First-Episode Psychosis: A Genetic Exploration in an Italian Cohort.Genes · 2025Article
- Endophenotype 2.0: updated definitions and criteria for endophenotypes of psychiatric disorders, incorporating new technologies and findings.Translational psychiatry · 2024Review
- Associations between antagonistic SNPs for neuropsychiatric disorders and human brain structure.Translational psychiatry · 2024Article
- A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.medRxiv : the preprint server for health sciences · 2024Article
- Investigating trait variability of gene co-expression network architecture in brain by controlling for genomic risk of schizophrenia.PLoS genetics · 2023Article
- Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities.Schizophrenia bulletin · 2023Article
- Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy.Nature human behaviour · 2023Article
- Mediating role of coping styles on the relationship between personality types and mental disorders in cardiovascular patients: a cross-sectional study in Iran.BMC psychiatry · 2023Article
- Exploring the genetics of rhythmic perception and musical engagement in the Vanderbilt Online Musicality Study.Annals of the New York Academy of Sciences · 2023Article
- New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Article
- Genetic assortative mating for schizophrenia and bipolar disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis.Translational psychiatry · 2022Article
- Causal influences of neuroticism on mental health and cardiovascular disease.Human genetics · 2021Article
- Identification of pleiotropy at the gene level between psychiatric disorders and related traits.Translational psychiatry · 2021Article
- Accurate error control in high-dimensional association testing using conditional false discovery rates.Biometrical journal. Biometrische Zeitschrift · 2021Article
- The shared genetic architecture of schizophrenia, bipolar disorder and lifespan.Human genetics · 2021Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Five personality traits using a Bayesian statistical framework. Using summary statistics from genome-wide association studies (GWAS) on personality traits in the 23andMe cohort (n = 59,225) and schizophrenia in the Psychiatric Genomics Consortium cohort (n = 82,315), we evaluated overlap in common genetic variants. The Big Five personality traits neuroticism, extraversion, openness, agreeableness and conscientiousness were measured using a web implementation of the Big Five Inventory. Applying the conditional false discovery rate approach, we increased discovery of genetic loci and identified two loci shared between neuroticism and schizophrenia and six loci shared between openness and schizophrenia. The study provides new insights into the relationship between personality traits and schizophrenia by highlighting genetic loci involved in their common genetic etiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.