Evidence map›Paper›PMID 28533501›Full record

ArticleAnnals of transplantation2017

Post-Transplant Diabetes Mellitus After Kidney Transplant in Hispanics and Caucasians Treated with Tacrolimus-Based Immunosuppression.

Pedro W Baron, Sergio Infante, Regina Peters, Jerusalem Tilahun, Jill Weissman, Lauren Delgado, Arputharaj Higgins Kore, W Lawrence Beeson, Michael E de Vera

3 registry-linked trialsOpen access · hybridAbstract read
In one paragraph

Article in Annals of transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06095492 narecruitingstarted 2023, after this paper: background citation

Effect of Empagliflozin Versus Linagliptin on Glycemic Outcomes, Renal Outcomes and Body Composition in Renal Transplant Recipients With Diabetes Mellitus: Randomized Controlled Trial (EmLina Renal Trial)

Ran2023Enrolled200Registered outcomes9Posted comparisons0ConditionsDiabetes Mellitus, Kidney Transplant; ComplicationsArmsempagliflozin 25 mg, Linagliptin
Open the trial in the graph
NCT06098625 naunknown statusstarted 2023, after this paper: background citation

Effect of Empagliflozin Versus Linagliptin on Glycemic Outcomes, Renal Outcomes and Body Composition in Renal Transplant Recipients With Diabetes Mellitus: Randomized Controlled Trial

Ran2023Enrolled200Registered outcomes13Posted comparisons0ConditionsDiabetes Mellitus, Kidney Transplant; ComplicationsArmsempagliflozin 25 mg, Linagliptin 5 mg Oral Tablet
Open the trial in the graph
NCT05316038 unknown statusnot on this mapstarted 2022, after this paper: background citation

Study of the Impact of Belatacept Conversion on Metabolic and Infectious Complications in Kidney Transplant Recipients at Grenoble-Alpes University Hospital

TypeobservationalSponsorUniversity Hospital, GrenobleRan2022 to 2024Enrolled100ConditionsKidney Transplant Infection, Cardiovascular Diseases, Immunosuppression, Kidney TransplantArmsOral glucose tolerance test
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Prognostic impact of post-transplant diabetes mellitus in kidney allograft recipients: a meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Pooled it
  2. Review
  3. Article
  4. Diabetes and Cardiovascular Risk in Renal Transplant Patients.International journal of molecular sciences · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Pedro W BaronTransplantation Institute, Loma Linda University Medical Center, Loma Linda, CA, USA.
Sergio InfanteDepartment of Internal Medicine, Division of Nephrology, Loma Linda University Medical Center, Loma Linda, CA, USA.
Regina PetersSchool of Pharmacy, Loma Linda University, Loma Linda, CA, USA.
Jerusalem TilahunDepartment of Internal Medicine, Division of Nephrology, Loma Linda University Medical Center, Loma Linda, CA, USA.
Jill WeissmanSchool of Pharmacy, Loma Linda University, Loma Linda, CA, USA.
Lauren DelgadoDepartment of Surgery, Loma Linda University Medical Center, Loma Linda, CA, USA.
Arputharaj Higgins KoreTransplantation Institute, Loma Linda University Medical Center, Loma Linda, CA, USA.
W Lawrence BeesonCenter for Nutrition, Healthy Lifestyle and Disease Prevention, School of Public Health, Loma Linda University, Loma Linda, CA, USA.
Michael E de VeraTransplantation Institute, Loma Linda University Medical Center, Loma Linda, CA, USA.
Loma Linda University · USLoma Linda University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Development of post-transplant diabetes mellitus after kidney transplant (PTDM) significantly increases kidney graft loss and mortality. Several risk factors for PTDM have been reported, including Hispanic ethnicity and the use of calcineurin inhibitors and corticosteroids. The incidence and impact of PTDM in the Hispanic kidney transplant population is unknown. MATERIAL AND METHODS We retrospectively reviewed the medical records of 155 Hispanic and 124 Caucasian patients, who were not diabetics and underwent kidney transplant between January 2006 and December 2011. We analyzed their clinical outcomes at 12 months post-transplant, including the incidence of PTDM, acute rejection rates, and patient and graft survival. RESULTS Hispanics who developed PTDM (n=22) were more than 10 years older and had higher body mass index (BMI) than Hispanics without PTDM (p<0.001 and p=0.001, respectively). Caucasians with PTDM (n=13) were non-significantly older (2.5 years) and had higher BMI than Caucasians without PTDM (p=0.526, p=0.043, respectively). The incidence of PTDM was not significantly different between Hispanics and Caucasians treated with tacrolimus-based immunosuppression (14.2% and 10.5%, respectively). CONCLUSIONS PTDM did not cause significant difference in short-term outcomes after kidney transplant in Hispanics or Caucasians. Larger multicenter prospective and long-term clinical trials are needed to validate these findings.

Indexed as

AdultAge FactorsBody Mass IndexDiabetes MellitusFemaleHispanic or LatinoHumansImmunosuppressive AgentsIncidenceKidney Failure, ChronicKidney TransplantationMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesRisk FactorsImmunosuppressive AgentsTacrolimus

Identifiers

PMID28533501
PMCPMC6248042
OpenAlexW2618201887

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.