Evidence map›Paper›PMID 28533440›Full record

ArticleGenetics2017

The RNAi Inheritance Machinery of

George Spracklin, Brandon Fields, Gang Wan, Diveena Becker, Ashley Wallig, Aditi Shukla, Scott Kennedy

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 151 citations in OpenAlex.

  1. Article
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  7. Intraspecific variation in the duration of epigenetic inheritance.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
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  15. Morc1 reestablishes H3K9me3 heterochromatin on piRNA-targeted transposons in gonocytes.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Article
  17. Article
  18. ThemicroPublication biology · 2024
    Article
  19. Review
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

George SpracklinLaboratory of Genetics, University of Wisconsin-Madison, Madison, Wisconsin 53706.
Brandon FieldsLaboratory of Genetics, University of Wisconsin-Madison, Madison, Wisconsin 53706.
Gang WanDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115.
Diveena BeckerDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115.
Ashley WalligLaboratory of Genetics, University of Wisconsin-Madison, Madison, Wisconsin 53706.
Aditi ShuklaDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115.
Scott KennedyDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115 kennedy@genetics.med.harvard.edu.
Harvard University · USUniversity of Wisconsin–Madison · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Small Regulatory RNA Functions In The NucleusR01GM088289 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KENNEDY, SCOTT G · 2009 to 2022
$4.4M
Multi-Generational Epigenetic Inheritance and Germline ImmortalityR01GM104232 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KENNEDY, SCOTT G · 2013 to 2016
$1.4M
NIGMS NIH HHS R01 GM088289NIGMS NIH HHS R01 GM104232NIGMS NIH HHS T32 GM007133NIH HHS P40 OD010440
6 · The paper itself

Abstract

Gene silencing mediated by dsRNA (RNAi) can persist for multiple generations in

Indexed as

Gene SilencingAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsEpigenesis, GeneticPhenotypeRNA, Small InterferingCaenorhabditis elegans ProteinsRNA, Small InterferingCaenorhabditis elegansepigenetic inheritancesmall RNAs

Identifiers

PMID28533440
PMCPMC5500139
OpenAlexW2619990190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.