ArticleProceedings of the National Academy of Sciences of the United States of America2017
HDAC1 links early life stress to schizophrenia-like phenotypes.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 51 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Pooled it
- PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia.The Journal of clinical investigation · 2019Trial
- Early life experiences, the neural epigenome and affective disorder risk.Nature reviews. Neuroscience · 2026Review
- The histone deacetylase family in health and disease.Signal transduction and targeted therapy · 2026Review
- Exploring the roots of schizophrenia: Current research and future directions (Review).Experimental and therapeutic medicine · 2026Review
- Histone acetylation and methylation in rare diseases: from molecular mechanisms to clinical presentations.Frontiers in cell and developmental biology · 2026Review
- Understanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses.Biological psychiatry global open science · 2025Article
- Maternal immune activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells.Molecular psychiatry · 2025Article
- Epigenetics Modulators as Therapeutics for Neurological Disorders.Current pharmaceutical design · 2025Review
- Importin α4 deficiency induces psychiatric disorder-related behavioral deficits and neuroinflammation in mice.Translational psychiatry · 2024Article
- Enduring Neurobiological Consequences of Early-Life Stress: Insights from Rodent Behavioral Paradigms.Biomedicines · 2024Review
- Class 1 histone deacetylases differentially modulate memory and synaptic genes in a spatial and temporal manner in aged and APP/PS1 mice.Brain research · 2024Article
- Systemic histone deacetylase inhibition ameliorates the aberrant responses to acute stress in socially isolated male mice.The Journal of physiology · 2024Article
- Epigenetic Regulation in Schizophrenia: Focus on Methylation and Histone Modifications in Human Studies.Genes · 2024Review
- HDAC1: An Essential and Conserved Member of the Diverse ZnInternational journal of molecular sciences · 2023Article
- Site-specific pathophysiology in a neonatal mouse model of gastroparesis.Neurogastroenterology and motility · 2023Article
- Narrative Review of the Complex Interaction between Pain and Trauma in Children: A Focus on Biological Memory, Preclinical Data, and Epigenetic Processes.Children (Basel, Switzerland) · 2023Review
- The Effect of Probiotic Supplementation on the Gut-Brain Axis in Psychiatric Patients.Current issues in molecular biology · 2023Review
- Epigenetic and epitranscriptomic regulation of axon regeneration.Molecular psychiatry · 2023Review
- Contribution of the Roman rat lines/strains to personality neuroscience: neurobehavioral modeling of internalizing/externalizing psychopathologies.Personality neuroscience · 2023Review
Corrections and comments
- Erratum issued
Authors and funding
36 authors at 11 institutions in 3 countries.
Sanaz Bahari-JavanDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, 37077 Goettingen, Germany.
Hristo VarbanovMolecular Neuroplasticity Group, German Center for Neurodegenerative Diseases Magdeburg, 39120 Magdeburg, Germany.
Rashi HalderDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases Goettingen, 37077 Goettingen, Germany.
Eva BenitoDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases Goettingen, 37077 Goettingen, Germany.
Lalit KauraniDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, 37077 Goettingen, Germany.
Susanne BurkhardtDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, 37077 Goettingen, Germany.
Heike Anderson-SchmidtDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, 37077 Goettingen, Germany.
Ion AnghelescuPrivat-Nerven-Klinik Dr. med. Kurt Fontheim, 38704 Liebenburg, Germany.
Monika BuddeDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, 37077 Goettingen, Germany.
Roman M StillingResearch Group for Genome Dynamics in Brain Diseases, 37077 Goettingen, Germany.
Joan CostaHospital Sant Joan de Deu, 08830 Sant Bio de Llobregat, Spain.
Juan MedinaHospital Sant Joan de Deu, 08830 Sant Bio de Llobregat, Spain.
Detlef E DietrichCenter of Mental Health, Hannover Medical School, Burghof-Klinik Rinteln, 31737 Rinteln, Germany.ORCID 0000-0002-1159-6538
Christian FiggeKarl-Jaspers-Klinik, Wehnen, 26160 Bad Zwischenahn, Germany.
Here FolkertsDepartment of Psychiatry, Psychology, and Psychosomatics, Reinhard-Nieter-Krankenhaus, 26389 Wilhelmshaven, Germany.
Katrin GadeDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, 37077 Goettingen, Germany.
Urs HeilbronnerDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, 37077 Goettingen, Germany.
Manfred KollerASKLEPIOS Fachklinikum Göttingen, 37081 Goettingen, Germany.
Carsten KonradDepartment of Psychiatry, Agaplesion-Diakonieklinikum Rotenburg, 27356 Rotenburg (Wuemme), Germany.
Sara Y NussbeckDepartment of Medical Informatics, University Medical Center Goettingen, 37075 Goettingen, Germany.
Harald ScherkAMEOS Klinikum Osnabrück, 49088 Osnabrueck, Germany.
Carsten SpitzerASKLEPIOS Fachklinikum Tiefenbrunn, Tiefenbrunn, 37124 Rosdorf, Germany.
Sebastian StierlPsychiatric Community Hospital Lueneburg, 21339 Lueneburg, Germany.
Judith StöckelPsychiatric Community Hospital Lueneburg, 21339 Lueneburg, Germany.
Andreas ThielDepartment of Psychiatry, Agaplesion-Diakonieklinikum Rotenburg, 27356 Rotenburg (Wuemme), Germany.
Martin von HagenCenter for Psychiatry and Psychotherapy, Klinikum Werra-Meissner, 37269 Eschwege, Germany.
Jörg ZimmermannCenter of Mental Health, Hannover Medical School, Burghof-Klinik Rinteln, 31737 Rinteln, Germany.
Antje ZitzelsbergerDepartment of Psychiatry, Psychology, and Psychosomatics, Reinhard-Nieter-Krankenhaus, 26389 Wilhelmshaven, Germany.
Sybille SchulzCenter for Psychiatry, Klinikum Bremen-Ost, 28325 Bremen, Germany.
Andrea SchmittDepartment of Psychiatry and Psychotherapy, Medical Center of the University of Munich, 80336 Munich, Germany.
Ivana DelalleDepartment of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118.
Peter FalkaiDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, 37077 Goettingen, Germany.
Thomas G SchulzeDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, 37077 Goettingen, Germany.
Alexander DityatevMolecular Neuroplasticity Group, German Center for Neurodegenerative Diseases Magdeburg, 39120 Magdeburg, Germany.
Farahnaz SananbenesiResearch Group for Genome Dynamics in Brain Diseases, 37077 Goettingen, Germany.
André FischerDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, 37077 Goettingen, Germany; andre.fischer@dzne.de.
University of Göttingen · DEGerman Center for Neurodegenerative Diseases · DEBrain (Germany) · DEAgaplesion Diakonieklinikum Rotenburg · DEKlinikum Lüneburg · DEMedizinische Hochschule Hannover · DEUniversidade de São Paulo · BRAsklepios Fachklinikum Tiefenbrunn · DEBoston University · USKlinikum Bremen-Mitte · DEKlinikum Osnabrück · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a devastating disease that arises on the background of genetic predisposition and environmental risk factors, such as early life stress (ELS). In this study, we show that ELS-induced schizophrenia-like phenotypes in mice correlate with a widespread increase of histone-deacetylase 1 (
Indexed as
AdultAgedAnimalsDNA MethylationFemaleHippocampusHistone Deacetylase 1Histone Deacetylase InhibitorsHumansMaleMiceMice, Inbred C57BLMice, Mutant StrainsMice, TransgenicMiddle AgedPhenotypeHDAC1 protein, humanHdac1 protein, mouseHistone Deacetylase 1Histone Deacetylase InhibitorsRNA, Messengerearly life stressHDAC inhibitorhistone-deacetylasespersonalized medicineschizophrenia
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.